Vertex Pharmaceuticals Reports Third Quarter 2007 Financial Results and Provides Development Pipeline Update Important telaprevir data to be presented at AASLD Additional compounds for HCV and Cystic Fibrosis scheduled to enter development Cambridge, MA, October 29, 2007 Vertex
<i>-Phase 3 registration programs in hepatitis C and cystic fibrosis on
track-</i><br /><i>-Vertex to present telaprevir SVR data from Study C208 at AASLD
meeting this week-</i><br />
<i>-Hepatitis C:</i> <i>New Drug Application submission for telaprevir
on track for fourth quarter 2010-</i>
<br />
<i>-Cystic Fibrosis:</i> <i>Phase 3 registration program ongoing for
VX-770-</i>
<br />
<i>-Pipeline:</i> <i>Ongoing proof-of-concept clinical trials in
hepatitis C, cystic fibrosis, epilepsy and rheumatoid arthritis-</i>
<br />
<i>-Financial:</i> <i>Company ends third quarter with a cash position of
$1.2 billion-</i>
<br />
--Telaprevir data in HCV patients who failed current therapies to<br> be presented at EASL--<br><br> --Pharmacokinetic analyses in HCV patients show potential for<br> twice-daily dosing of telaprevir--<br><br> --VX-770 for cystic fibrosis to advance based on positive results<br> reported in March 2008--
<i>- Telaprevir registration program on track; VCH-222 enters
multi-dose, 3-day viral kinetic study -</i><i>- VX-770 will start registration program in CF patients with G551D
mutation -</i><i>-Vertex ends first quarter with $869 million of cash, cash
equivalents and marketable securities-</i>
CAMBRIDGE, Mass., Jun 03, 2008 (BUSINESS WIRE) -- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that it has sold its rights to future royalties in Lexiva(R) and Agenerase(R) under its 1993 license agreement with GlaxoSmithKline plc (GSK) in the field of HIV protease inhibitors
<i>- Vertex to acquire privately-held ViroChem Pharma in cash and stock
transaction -</i><i>- Two HCV polymerase inhibitors, VCH-222 and VCH-759, have
demonstrated significant antiviral activity in early clinical trials -</i><i>- First STAT-C combination trial with telaprevir planned for 2H 2009
start -</i>
-- Primary Phase 3 trial will focus on studying 24-week telaprevir-based regimens -- Vertex plans concurrent second study to support registration -- Final data from both trials anticipated in mid- 2010
Vertex Pharmaceuticals to Focus 2006 Clinical Development on Therapies for Hepatitis C Virus Infection, Inflammation and Cystic Fibrosis Cambridge, MA, October 4, 2005 - Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) announced today that it will concentrate its development investment in 2006 on
