Institutional Investors and Financial Analysts, please contact:

Main email: investorinfo@vrtx.com
Main phone: 617-961-7163

Michael Partridge
Senior Vice President, Investor Relations
617-341-6108

Manisha Pai
Executive Director, Investor Relations
617-961-1899

Miroslava Minkova
Executive Director, Investor Relations
617-341-6135

Contact Vertex's Transfer Agent
Communication regarding transfer requirements, lost certificates and changes of address should be directed to:

Computershare Investor Services
P.O Box 43023
Providence, RI 02940-3023
Telephone: +1 781-575-2879
Fax: +1 781-575-3605