Institutional Investors and Financial Analysts, please contact:

Main email: investorinfo@vrtx.com
Main phone: 617-961-7163

Michael Partridge
Senior Vice President, Investor Relations
617.341.6108

Zach Barber
Senior Director, Investor Relations
617.341.6470

Brenda Eustace
Director, Investor Relations
617.341.6187

Contact Vertex's Transfer Agent
Communication regarding transfer requirements, lost certificates and changes of address should be directed to:

Computershare Investor Services
P.O Box 43023
Providence, RI 02940-3023
Telephone: +1 781-575-2879
Fax: +1 781-575-3605