Vertex is listed on The Nasdaq Global Select Market under the ticker symbol VRTX.

The CUSIP # for Vertex's securities is 92532F.

Vertex is headquartered in Boston, Massachusetts.

No. Vertex does not have a direct stock purchase plan. You may purchase shares of Vertex through a broker.

Vertex's transfer agent is Computershare. You can reach Computershare at:

Computershare Investor Services
P.O. Box 43006
Providence, RI 02940-3006
877-373-6374
Website: www-us.computershare.com

In the event that you lose your stock certificates, you should contact our transfer agent, Computershare.

Computershare Investor Services
P.O. Box 43006
Providence, RI 02940-3006
877-373-6374
Website: www-us.computershare.com

If you change your address, you should contact our transfer agent, Computershare.

Computershare Investor Services
P.O. Box 43006
Providence, RI 02940-3006
877-373-6374
Website: www-us.computershare.com