Matures within one year Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One Business Acquisition [Axis] Business Acquisition [Axis] Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] British pound sterling United Kingdom, Pounds Deferred tax assets Deferred Income Tax Assets, Net Entity Address, Postal Zip Code Entity Address, Postal Zip Code Debt covenant, consolidated leverage ratio Debt Covenant, Consolidated Leverage Ratio Consolidated leverage ratio that must be maintained in order to be in compliance with debt covenants. Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Unrealized holding losses on marketable securities, net Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Line of credit facility, maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Schedule of Cash Equivalents and Marketable Securities Cash, Cash Equivalents and Investments [Table Text Block] Financial Instruments [Domain] Financial Instruments [Domain] Basis spread on variable rate (as a percent) Debt Instrument, Basis Spread on Variable Rate Statistical Measurement [Domain] Statistical Measurement [Domain] Indefinite-Lived Intangible Assets, Major Class Name [Domain] Indefinite-Lived Intangible Assets, Major Class Name [Domain] Schedule of Fair Value of Our Contingent Consideration Liabilities Schedule of Business Acquisitions by 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Cash Provided by (Used in) Operating Activities [Abstract] All Currencies [Domain] All Currencies [Domain] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Costs and expenses: Costs and Expenses [Abstract] CRISPR A&R JDCA CRSIPR A&R JDCA [Member] CRISPR Amended and restated the Original CTX001 JDCA Legal Entity [Axis] Legal Entity [Axis] Total liabilities Liabilities Time deposits Bank Time Deposits [Member] Verve Verve [Member] Verve Share-based Compensation Arrangement by Share-based Payment Award Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Geographical [Axis] Geographical [Axis] Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Cash and cash equivalents Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents Accrued expenses Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Schedule of Foreign Exchange Contracts, Condensed Consolidated Statements of Operations Reclassification out of Accumulated Other Comprehensive Income [Table Text Block] Other current liabilities, foreign currency forward contracts Derivative Liability, Current Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value Hierarchy and NAV [Domain] Schedule of Collaborative Arrangement Costs Collaborative Arrangement and Arrangement Other than Collaborative [Table Text Block] Revolving Credit Facility Revolving Credit Facility [Member] Collaborative Arrangement, Transaction with Party to Collaborative Arrangement Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member] Australian dollar Australia, Dollars On Available-For-Sale Debt Securities AOCI, Accumulated Gain (Loss), Debt 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Deferred Liability Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-Sale [Table] Derivative Instruments, Gain (Loss) [Table] Derivative Instruments, Gain (Loss) [Table] Schedule of Accumulated Other Comprehensive Income (Loss) Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Total assets Assets Net income per common share: Earnings Per Share [Abstract] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Axis] Fair Value Equity Securities, FV-NI, Current Antidilutive Securities [Axis] Antidilutive Securities [Axis] Accrued expenses Accrued Liabilities, Current Stock-based compensation expense: Share-based Compensation Allocation [Abstract] -- None. No documentation exists for this element. -- Net cash used in financing activities Net Cash Provided by (Used in) Financing Activities Accounting Policies [Abstract] Accounting Policies [Abstract] Number of shares authorized to be repurchased Stock Repurchase Program, Authorized Amount Amounts reclassified from accumulated other comprehensive income (loss) Reclassification from AOCI, Current Period, Net of Tax, Attributable to Parent Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Income before provision for income taxes Income before provision for income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Earnings Per Share Earnings Per Share [Text Block] Other long-term liabilities Other Noncurrent Liabilities [Member] Long-term finance lease liabilities Finance Lease, Liability, Noncurrent KALYDECO KALYDECO [Member] KALYDECO inventories, net Schedule of Provision for (Benefits from) Income Taxes and Effective Tax rates Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Award Type [Domain] Award Type [Domain] Gross Unrealized Gains Equity Securities, FV-NI, Unrealized Gain Derivative Contract [Domain] Derivative Contract [Domain] ORKAMBI ORKAMBI [Member] ORKAMBI [Member] Entity Registrant Name Entity Registrant Name Foreign Currency Translation Adjustment Foreign Currency Forward Contract Accumulated Foreign Currency Adjustment Attributable to Parent [Member] Entity Address, City or Town Entity Address, City or Town On Foreign Currency Forward Contracts Accumulated Gain (Loss), Net, Cash Flow Hedge, Parent [Member] Collaborative arrangement, development and regulatory potential milestone payments maximum Collaborative Arrangement Development And Regulatory Potential Milestone Payments Maximum Represents the potential milestone amount to be paid by the entity under the collaboration agreement if drug candidates are approved and commercialized. Minimum Minimum [Member] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Entity Emerging Growth Company Entity Emerging Growth Company Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Raw materials Inventory, Raw Materials, Net of Reserves Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Trading Symbol Trading Symbol Entity File Number Entity File Number Up-front payment Collaborative Arrangement Up-front License Fee Collaborative Arrangement Up-front License Fee Accumulated Other Comprehensive Income (Loss) [Line Items] Accumulated Other Comprehensive Income (Loss) [Line Items] Collaborative arrangement costs Research and Development Expense Investment in equity securities and notes receivable Payment To Acquire Preferred Stock and Notes Receivable Payment To Acquire Preferred Stock and Notes Receivable Prepaid expenses and other current assets Restricted Cash and Cash Equivalents Restricted stock units (including PSUs) Unvested restricted stock units (including PSUs) Restricted Stock Units (RSUs) [Member] Effective tax rate Effective Income Tax Rate Reconciliation, Percent Use of Estimates Use of Estimates, Policy [Policy Text Block] Cash equivalents: Fair Value Cash and Cash Equivalents, Fair Value Disclosure Business Combination Business Combination Disclosure [Text Block] Accounts payable Increase (Decrease) in Accounts Payable Total purchase price Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net Income Taxes Income Tax Disclosure [Text Block] Finished goods Inventory, Finished Goods, Net of Reserves Credit Facility [Domain] Credit Facility [Domain] Amortized Cost Debt and Equity Securities, Cost Debt and Equity Securities, Cost Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Collaborative Arrangements by Agreement [Axis] Collaborative Arrangements by Agreement [Axis] Significant terms of collaboration arrangements, by individual agreement. Basic (in dollars per share) Basic net income per common share (in dollars per share) Earnings Per Share, Basic Other Assets Other assets Other Assets [Member] Counterparty Name [Domain] Counterparty Name [Domain] Indefinite-Lived Intangible Assets [Axis] Indefinite-Lived Intangible Assets [Axis] Total shareholders’ equity Beginning balance Ending balance Stockholders' Equity Attributable to Parent Hedging Derivative Instruments and Hedging Activities Disclosure [Text Block] Allowance for credit loss for available-for-sale debt securities Debt Securities, Available-for-Sale, Allowance for Credit Loss Line of Credit Facility [Line Items] Line of Credit Facility [Line Items] Derivative Instruments, Gain (Loss) [Line Items] Derivative Instruments, Gain (Loss) [Line Items] Entity Interactive Data Current Entity Interactive Data Current Prepaid expenses and other current assets Prepaid Expenses and Other Current Assets [Member] Government-sponsored enterprise securities Government-sponsored enterprise securities US Government-sponsored Enterprises Debt Securities [Member] Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Money market funds Money Market Funds [Member] Retained Earnings Retained Earnings [Member] Common Stock Common Stock [Member] Schedule of Stock-based Compensation Expense by Line Item Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Total other comprehensive income Other comprehensive income, net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Other comprehensive (loss) income before reclassifications OCI, before Reclassifications, Net of Tax, Attributable to Parent Repurchases of common stock Payments for Repurchase of Common Stock Balance at December 31, 2021 Balance at September 30, 2022 Business Combination, Contingent Consideration, Liability Statement [Table] Statement [Table] Commercial paper Commercial Paper, Not Included with 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Basis Fair Value, Recurring [Member] Net other assets Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net Other Assets Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net Other Assets Remaining milestone payment Business Combination, Remaining Milestone Payment Business Combination, Remaining Milestone Payment Total collaborative arrangement costs included in costs and expenses Costs And Expenses [Member] Costs And Expenses Document Fiscal Year Focus Document Fiscal Year Focus Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Statement [Line Items] Statement Statement [Line Items] Payments on finance leases Finance Lease, Principal Payments Variable Rate [Domain] Variable Rate [Domain] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Selling, general and administrative expenses Selling, General and Administrative Expense Canadian dollar Canada, Dollars Change in fair value of contingent consideration Decrease in fair value of contingent consideration Decrease in fair value of contingent payments Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Operating lease assets Operating Lease, Right-of-Use Asset Product revenues, net Product [Member] Repurchase of common stock Value of shares repurchased Stock Repurchased During Period, Value Accumulated Other Comprehensive (Loss) Income Total AOCI Attributable to Parent [Member] Accumulated Other Comprehensive Income (Loss) Comprehensive Income (Loss) Note [Text Block] Document Transition Report Document Transition Report Local Phone Number Local Phone Number Income from operations Operating Income (Loss) Inventories Increase (Decrease) in Inventories Equity securities without readily determinable fair value, amount Equity Securities without Readily Determinable Fair Value, Amount Effect of potentially dilutive securities: Weighted Average Number of Shares Outstanding, Diluted, Adjustment [Abstract] Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Goodwill Goodwill Other current liabilities Other Current Liabilities [Member] Gross Unrealized Losses Equity Securities, FV-NI, Unrealized Loss Repurchase of common stock (in shares) Shares repurchased (in shares) Stock Repurchased During Period, Shares Indefinite-lived intangible assets Indefinite-Lived Intangible Assets Acquired Provision for income taxes Income Tax Expense (Benefit) Geographical [Domain] Geographical [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Income Statement [Abstract] Income Statement [Abstract] Hedging Relationship [Axis] Hedging Relationship [Axis] Additional Paid-in Capital Additional Paid-in Capital [Member] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Document Fiscal Period Focus Document Fiscal Period Focus Cost of sales Cost of Goods and Services Sold Derivative [Line Items] Derivative [Line Items] Diluted (in shares) Diluted weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Diluted Gross Amounts Presented Derivative Liability Schedule of Inventories by Type Schedule of Inventory, Current [Table Text Block] Total liabilities Gross Amounts Recognized Derivative Liability, Subject to Master Netting Arrangement, before Offset Contingent liabilities Contingent Liabilities Contingent Liabilities Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-Sale [Line Items] Base Rate Base Rate [Member] Marketable securities: Marketable Securities Common stock, $0.01 par value; 500,000,000 shares authorized, 256,645,737 and 254,479,046 shares issued and outstanding, respectively Common Stock, Value, Issued Business Acquisition, Acquiree [Domain] Business Acquisition, Acquiree [Domain] Schedule of Potential Gross Common Equivalent Shares Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of Financial Assets Subject to Fair Value Measurements Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Proceeds from finance leases Proceeds From Finance Leases Proceeds From Finance Leases Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Cash, cash equivalents and restricted cash—beginning of period Cash, cash equivalents and restricted cash—end of period Cash, cash equivalents and restricted cash per condensed consolidated statement of cash flows Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Current liabilities: Liabilities, Current [Abstract] Foreign Currency Forward Contracts Foreign Exchange Forward [Member] Common stock, shares issued (in shares) Common Stock, Shares, Issued Indemnification claims Indemnification Claims Amount of indemnification claims currently outstanding Schedule of Company's Net Unrealized (Losses) Gains on Corporate Equity Securities Unrealized Gain (Loss) on Investments [Table Text Block] Reclassification out of Accumulated Other Comprehensive Income Reclassification out of Accumulated Other Comprehensive Income [Member] Income Statement Location [Domain] Income Statement Location [Domain] Income Statement Location [Domain] Cash Flow Hedging Cash Flow Hedging [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Debt covenant, increase in consolidated leverage ratio Debt Covenant, Increase In Consolidated Leverage Ratio Debt Covenant, Increase In Consolidated Leverage Ratio Offsetting Derivative Liabilities [Abstract] Offsetting Derivative Liabilities [Abstract] Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Table] Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Table] Schedule of the cash and cash equivalents and available-for-sale investments held by the entity. Amendment Flag Amendment Flag Catalyst Biosciences Catalyst Biosciences [Member] Catalyst Biosciences Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Legal Offset Derivative Asset, Fair Value, Offset Against Collateral, Net of Not Subject to Master Netting Arrangement, Policy Election Comprehensive income Comprehensive Income (Loss), Net of Tax, Attributable to Parent Issuances of common stock under benefit plans Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised ViaCyte ViaCyte [Member] ViaCyte Gross Unrealized Gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Entity Current Reporting Status Entity Current Reporting Status Other current liabilities Other Liabilities, Current Other assets Other Assets, Noncurrent Unrealized gains (losses) on foreign currency forward contracts, tax Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), after Reclassification, Tax, Parent Depreciation expense Depreciation, Depletion and Amortization Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Counterparty Name [Axis] Counterparty Name [Axis] Schedule of Assets Acquired and Liabilities Assumed Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block] Derivative [Table] Derivative [Table] Accumulated Other Comprehensive Income (Loss) [Table] Accumulated Other Comprehensive Income (Loss) [Table] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Effect of changes in exchange rates on cash Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Continuing Operations Cash equivalents: Cash and Cash Equivalents [Abstract] Currency [Axis] Currency [Axis] Stock options Stock options Share-Based Payment Arrangement, Option [Member] Other income (expense), net Other income (expense), net Other Nonoperating Income (Expense) Balance Sheet Location [Axis] Balance Sheet Location [Axis] Basis of Presentation and Accounting Policies Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Common stock, shares authorized (in shares) Common Stock, Shares Authorized Long-term contingent consideration Long-term contingent consideration Business Combination, Contingent Consideration, Liability, Noncurrent Swiss Franc Switzerland, Francs Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest [Abstract] Statement of Comprehensive Income [Abstract] Maximum Maximum [Member] Accumulated other comprehensive income Accumulated Other Comprehensive Income (Loss), Net of Tax CRISPR CRISPR [Member] CRISPR Schedule of Business Acquisitions, by Acquisition [Table] Schedule of Business Acquisitions, by Acquisition [Table] Cash and cash equivalents Amortized Cost Cash and Cash Equivalents, at Carrying Value Total current assets Assets, Current Designated as Hedging Instruments Designated as hedging instruments Designated as Hedging Instrument [Member] Cash paid for income taxes Income Taxes Paid, Net Business Acquisition [Line Items] Business Acquisition [Line Items] Entity Small Business Entity Small Business Unrealized gains on foreign currency forward contracts, net of tax of $(16.0), $(9.6), $(34.3) and $(21.2), respectively Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), after Reclassification and Tax, Parent Beginning balance (in shares) Ending balance (in shares) Shares, Outstanding Measurement Frequency [Domain] Measurement Frequency [Domain] Revenues: Revenues [Abstract] Summary of cash, cash equivalents and marketable securities Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Line Items] -- None. No documentation exists for this element. -- Line of Credit Facility [Table] Line of Credit Facility [Table] Purchases of available-for-sale debt securities Payments to Acquire Debt Securities, Available-for-Sale Intangible asset Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Indefinite-Lived Intangible Assets Issuance of common stock under benefit plans (in shares) Stock Issued During Period, Shares, Employee Benefit Plan Income tax effect Share-Based Payment Arrangement, Expense, Tax Benefit Accounts receivable, net Increase (Decrease) in Accounts Receivable Title of 12(b) Security Title of 12(b) Security Share Repurchase Program 2020 Share Repurchase Program 2020 [Member] Share Repurchase Program 2020 Total costs and expenses Costs and Expenses Class of Treasury Stock [Table] Class of Treasury Stock [Table] Other assets, foreign currency forward contracts Derivative Asset, Noncurrent Business Combination and Asset Acquisition [Abstract] Selling, general and administrative expenses Selling, General and Administrative Expenses [Member] Investments, Debt and Equity Securities [Abstract] Investments, Debt and Equity Securities [Abstract] Liabilities and Shareholders’ Equity Liabilities and Equity [Abstract] Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent U.S. Treasury securities US Treasury Securities [Member] Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Marketable Securities and Equity Investments Cash, Cash Equivalents, and Marketable Securities [Text Block] Share Repurchase Program 2021 Share Repurchase Program 2021 [Member] Share Repurchase Program 2021 Shares used in per share calculations: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Inventories Total Inventory, Net CRISPR Therapeutics CRISPR Therapeutics AG [Member] CRISPR Therapeutics AG Accounts payable Accounts Payable, Current Allocation of net profits and net losses, percent Collaborative Arrangement, Allocation Of Net Profits And Losses, Percent Collaborative Arrangement, Allocation Of Net Profits And Losses, Percent Gross Unrealized Gains Debt and Equity Securities, Unrealized Gain Debt and Equity Securities, Unrealized Gain Amortized Cost Equity Securities, FV-NI, Cost Hedging Relationship [Domain] Hedging Relationship [Domain] Hedging Designation [Axis] Hedging Designation [Axis] Entity Filer Category Entity Filer Category Gross Amounts Offset Derivative Asset, Subject to Master Netting Arrangement, Liability Offset Shareholders’ equity: Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest [Abstract] Basic (in shares) Basic weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Basic United States UNITED STATES Marketable securities Marketable Securities [Member] Marketable Securities [Member] Financial instruments carried at fair value (liability positions): Liabilities, Fair Value Disclosure [Abstract] Asset acquisition, consideration transferred Asset Acquisition, Consideration Transferred Schedule of Foreign Exchange Contracts Schedule of Foreign Exchange Contracts, Statement of Financial Position [Table Text Block] Total stock-based compensation expense included in “Total costs and expenses” Share-Based Payment Arrangement, Expense Commitments and contingencies Commitments and Contingencies Security Exchange Name Security Exchange Name Legal Offset Derivative Liability, Fair Value, Offset Against Collateral, Net of Not Subject to Master Netting Arrangement, Policy Election Notional amount of foreign currency forward contract Derivative, Notional Amount Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding Preferred Stock, Value, Issued Restricted stock units (including PSUs) Restricted Stock [Member] TRIKAFTA/KAFTRIO TRIKAFTA/KAFTRIO [Member] TRIKAFTA/KAFTRIO [Member] Gross Amounts Not Offset Derivative Asset, Subject to Master Netting Arrangement, Deduction of Financial Instrument Not Offset Revenues Revenue from Contract with Customer, Excluding Assessed Tax Cash equivalents: Cash and cash equivalents Cash and Cash Equivalents [Member] Cover [Abstract] Cover [Abstract] Level 3 Fair Value, Inputs, Level 3 [Member] Stock-based Compensation Expense and Share Repurchase Programs Share-Based Payment Arrangement [Text Block] Work-in-process Inventory, Work in Process, Net of Reserves Revenue Recognition Revenue from Contract with Customer [Text Block] Derivative asset current, foreign currency forward contracts Derivative Asset, Current Interest expense Interest Income (Expense), Net Payments in connection with common stock withheld for employee tax obligations Payment, Tax Withholding, Share-Based Payment Arrangement Total liabilities and shareholders’ equity Liabilities and Equity Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Stock repurchase program, remaining amount Stock Repurchase Program, Remaining Authorized Repurchase Amount Cash Cash Share-based payment arrangements (in shares) Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements Total product revenues outside of the United States Non-US [Member] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Not Designated as Hedging Instrument Not designated as hedging instruments Not Designated as Hedging Instrument [Member] AOCI Attributable to Parent, Net of Tax [Roll Forward] AOCI Attributable to Parent, Net of Tax [Roll Forward] Payment to acquire ViaCyte, Inc., net of cash acquired Payments to Acquire Businesses, Net of Cash Acquired Level 2 Fair Value, Inputs, Level 2 [Member] Goodwill expected to be tax deductible Business Acquisition, Goodwill, Expected Tax Deductible Amount Current Fiscal Year End Date Current Fiscal Year End Date Marketable securities Marketable Securities, Current Intangible assets Intangible Assets, Net (Excluding Goodwill) Diluted (in dollars per share) Diluted net income per common share (in dollars per share) Earnings Per Share, Diluted Gross Amounts Not Offset Derivative Liability, Subject to Master Netting Arrangement, Deduction of Financial Instrument Not Offset Stock-based compensation expense APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Total current liabilities Liabilities, Current Total stock-based compensation expense included in “Total costs and expenses” Share-Based Payment Arrangement, Expensed and Capitalized, Amount Other Other, Non U.S. [Member] Other, Non U.S. [Member] Corporate equity securities Equity Securities [Member] Net unrecognized tax benefits which would affect the tax rate if recognized Unrecognized Tax Benefits that Would Impact Effective Tax Rate Share Repurchase Program [Axis] Share Repurchase Program [Axis] Corporate debt securities Corporate Debt Securities [Member] Gross Amounts Offset Derivative Liability, Subject to Master Netting Arrangement, Asset Offset Gains (losses) on equity securities Equity Securities, FV-NI, Unrealized Gain (Loss) Equity, Class of Treasury Stock [Line Items] Equity, Class of Treasury Stock [Line Items] Offsetting Derivative Assets [Abstract] Offsetting Derivative Assets [Abstract] Total assets Gross Amounts Recognized Derivative Asset, Subject to Master Netting Arrangement, before Offset Discrete tax benefit associated with an increase in U.K.'s corporate tax rate Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount Entity Address, Address Line One Entity Address, Address Line One Other financing activities Proceeds from (Payments for) Other Financing Activities Stock-based compensation expense related to inventories Share-Based Payment Arrangement, Amount Capitalized Contract liabilities Contract with Customer, Liability Net unrealized gains (losses) Unrealized Gain (Loss) on Investments Impairment of intangible assets Impairment of Intangible Assets, Indefinite-Lived (Excluding Goodwill) Product and Service [Axis] Product and Service [Axis] Europe Europe [Member] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Fair Value Debt and Equity Securities, Fair Value Debt and Equity Securities, Fair Value Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Abstract] Total marketable debt securities Debt Securities, Available-for-Sale [Abstract] Credit Facility [Axis] Credit Facility [Axis] Inventories Inventory Disclosure [Text Block] Equity [Abstract] Equity [Abstract] Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Entity Tax Identification Number Entity Tax Identification Number Gross Unrealized Losses Debt and Equity Securities, Unrealized Loss Debt and Equity Securities, Unrealized Loss Schedule of Disaggregation of Revenue Disaggregation of Revenue [Table Text Block] Revenue from Contract with Customer [Abstract] Revenue from Contract with Customer [Abstract] Common stock withheld for employee tax obligations (in shares) Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation Employee stock purchase program (in shares) Incremental Common Shares Attributable to Dilutive Effect of Equity Unit Purchase Agreements Research and development expenses Research and Development Expense (Excluding Acquired in Process Cost) Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Net increase in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Issuance of common stock under benefit plans Stock Issued During Period, Value, Employee Benefit Plan Contingent consideration, measurement input (as a percent) Business Combination, Contingent Consideration, Liability, Measurement Input Commercial paper Commercial Paper [Member] Entity Central Index Key Entity Central Index Key Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Corporate equity securities Equity Securities, FV-NI and without Readily Determinable Fair Value [Abstract] Fair Value by Measurement Frequency [Axis] Measurement Frequency [Axis] Indefinite-Lived Intangible Assets [Axis] Finite-Lived Intangible Assets by Major Class [Axis] Common stock withheld for employee tax obligations Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Acquired In-Process Research and Development and Other Arrangements Collaborative Arrangement Disclosure [Text Block] Total purchase price Business Combination, Consideration Transferred Line of credit facility additional borrowing capacity Line Of Credit Facility Additional Borrowing Capacity Amount of increased borrowing capacity available in the future. Measurement Input Type [Axis] Measurement Input Type [Axis] Entity [Domain] Entity [Domain] City Area Code City Area Code Assets Assets [Abstract] Collaborative arrangement, right to exclusively license, number of targets Collaborative Arrangement, Right To License, Number Of Targets Collaborative Arrangement, Right To License, Number Of Targets Euro Euro Member Countries, Euro Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Maturities of available-for-sale debt securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Acquired in-process research and development expenses Research and Development in Process Total financial liabilities Financial Liabilities Fair Value Disclosure Stock-based compensation expense Share-Based Payment Arrangement, Noncash Expense Variable Rate [Axis] Variable Rate [Axis] Other long-term liabilities Other Liabilities, Noncurrent Other liabilities Increase (Decrease) in Other Operating Liabilities Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Research and development expenses Research and Development Expense [Member] Derivative term Derivative, Term of Contract Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Schedule of Earnings Per Share, Basic and Diluted Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Cost of sales Cost of Sales [Member] Schedule of Offsetting Assets Offsetting Assets [Table Text Block] Other long-term liabilities, foreign currency forward contracts Derivative Liability, Noncurrent