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0000875320 2 2023-01-01 2023-12-31 0000875320 3 2023-01-01 2023-12-31 iso4217:USD shares iso4217:USD shares pure false 0000875320 DEF 14A VERTEX PHARMACEUTICALS INC / MA <h1 id="xdx_800_eecd--PvpTableTextBlock_dU_zKYZhfNhBlOe" style="font: 24pt Arial, Helvetica, Sans-Serif; margin: 0pt">PAY VERSUS PERFORMANCE</h1> Pursuant to Item 402(v) of Regulation S-K, we are presenting information that describes the relationship between compensation actually paid, as computed under the rules prescribed by Item 402(v), to our NEOs and certain financial performance measures for the company’s five most recently completed fiscal years. For more information about our executive compensation program, refer to the Compensation Discussion and Analysis section of this proxy statement starting on page 50. <table cellpadding="0" cellspacing="0" id="xdx_306_zDncMyLpiUeb" style="font: 9pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; padding-left: 3pt; text-align: left"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Average</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap; padding-right: 3pt"> </td></tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; padding-left: 3pt; text-align: left"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Summary</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Average</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="6" style="white-space: nowrap; color: #431263; text-align: center">Total Shareholder</td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap; padding-right: 3pt"> </td></tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; padding-left: 3pt; text-align: left"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Summary</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Summary</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Compensation</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Compensation</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="6" style="white-space: nowrap; color: #431263; text-align: center">Return (Value of Initial</td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap; padding-right: 3pt"> </td></tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; padding-left: 3pt; text-align: left"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Compensation</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Compensation</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Compensation</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Compensation</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Table Total</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Actually Paid</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="6" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: center">Fixed $100 Investment)</td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap; padding-right: 3pt"> </td></tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; padding-left: 3pt; text-align: left"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Table Total for</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Table Total for</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Actually Paid to</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">Actually Paid to</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">for Non-CEO</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">to Non-CEO</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right">VRTX</td><td style="white-space: nowrap; color: #431263"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td> <td colspan="2" style="white-space: nowrap"> </td><td style="white-space: nowrap"> </td><td style="white-space: nowrap; color: #431263"> </td> <td colspan="2" style="white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Net Product</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; padding-left: 3pt; text-align: left">Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">CEO(1)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">CEO(2)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">CEO(1)(3)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">CEO(2)(4)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">NEOs(5)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">NEOs(6)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">TSR(7)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">NBI TSR(8)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Net Income(9)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Revenue(10)</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="width: 21%; text-align: left; padding-left: 3pt">2023</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98B_eecd--PeoTotalCompAmt_c20230101__20231231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEp_zVzZEPA9ZuZ2" style="width: 3%; text-align: right">20,594,441</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left"> </td><td style="width: 3%; text-align: right">N/A</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_986_eecd--PeoActuallyPaidCompAmt_c20230101__20231231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEpKDMp_znLtDN3aBl77" style="width: 3%; text-align: right">44,202,174</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left"> </td><td style="width: 3%; text-align: right">N/A</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_981_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_fKDUp_zcAYYYGYKFF9" style="width: 3%; text-align: right">7,376,771</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_986_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_fKDYp_z3RpihTZPNQ2" style="width: 3%; text-align: right">18,104,165</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_986_eecd--TotalShareholderRtnAmt_pp2d_c20230101__20231231_fKDcp_zh7JJqFUXzQ" style="width: 3%; text-align: right">245.54</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_980_eecd--PeerGroupTotalShareholderRtnAmt_pp2d_c20230101__20231231_fKDgp_zXg96rjRkxzh" style="width: 3%; text-align: right">148.72</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left; vertical-align: top">$</td><td style="width: 3%; text-align: right"> 3.6 Billion</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left; vertical-align: top">$</td><td style="width: 3%; text-align: right; padding-right: 3pt"> 9.9 Billion</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-left: 3pt">2022</td><td> </td> <td style="text-align: left">$</td><td id="xdx_988_eecd--PeoTotalCompAmt_c20220101__20221231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEp_zQi0qKxgQboe" style="text-align: right">15,864,497</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">N/A</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_986_eecd--PeoActuallyPaidCompAmt_c20220101__20221231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEpKDMp_zMBB4isznf1l" style="text-align: right">29,529,089</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">N/A</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--NonPeoNeoAvgTotalCompAmt_c20220101__20221231_fKDUp_zsqS4tR4Dip4" style="text-align: right">8,982,257</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98E_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20220101__20221231_fKDYp_z9OJpluiOLwb" style="text-align: right">18,263,330</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--TotalShareholderRtnAmt_pp2d_c20220101__20221231_fKDcp_z16WpCu8364i" style="text-align: right">174.27</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_989_eecd--PeerGroupTotalShareholderRtnAmt_pp2d_c20220101__20221231_fKDgp_zMGln76VPUSl" style="text-align: right">142.19</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left; vertical-align: top">$</td><td style="text-align: right">3.3 Billion</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left; vertical-align: top">$</td><td style="text-align: right; padding-right: 3pt">8.9 Billion</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="text-align: left; padding-left: 3pt">2021</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98C_eecd--PeoTotalCompAmt_c20210101__20211231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEp_zXMCkVoe0jo5" style="text-align: right">15,198,856</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">N/A</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_980_eecd--PeoActuallyPaidCompAmt_c20210101__20211231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEpKDMp_zHSlF5x7QC6f" style="text-align: right">18,341,489</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">N/A</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98C_eecd--NonPeoNeoAvgTotalCompAmt_c20210101__20211231_fKDUp_zanT0TCY28ng" style="text-align: right">7,193,835</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20210101__20211231_fKDYp_zLAn572XFS83" style="text-align: right">8,969,051</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--TotalShareholderRtnAmt_pp2d_c20210101__20211231_fKDcp_zhO8BHWYycfe" style="text-align: right">132.52</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--PeerGroupTotalShareholderRtnAmt_pp2d_c20210101__20211231_fKDgp_zMpCfkVAwUCb" style="text-align: right">158.20</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left; vertical-align: top">$</td><td style="text-align: right">2.3 Billion</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left; vertical-align: top">$</td><td style="text-align: right; padding-right: 3pt">7.6 Billion</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-left: 3pt">2020</td><td> </td> <td style="text-align: left">$</td><td id="xdx_989_eecd--PeoTotalCompAmt_c20200101__20201231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEp_zs44DTpVbcSi" style="text-align: right">9,111,359</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--PeoTotalCompAmt_c20200101__20201231__ecd--IndividualAxis__custom--JeffreyLeidenMember_fKDIp_zHHR4wF0bOJ" style="text-align: right">16,473,245</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_982_eecd--PeoActuallyPaidCompAmt_c20200101__20201231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_fKDEpKDMp_zFdnKQuWfLJ2" style="text-align: right">12,172,454</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_c20200101__20201231__ecd--IndividualAxis__custom--JeffreyLeidenMember_fKDIpKDQp_zOeIoHrGzDgd" style="text-align: right">31,319,824</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_982_eecd--NonPeoNeoAvgTotalCompAmt_c20200101__20201231_fKDUp_z83R8TgQvKL3" style="text-align: right">6,697,408</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_986_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20200101__20201231_fKDYp_zGHuj2ueMvT7" style="text-align: right">10,584,384</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--TotalShareholderRtnAmt_pp2d_c20200101__20201231_fKDcp_zoJHsSY0xMq8" style="text-align: right">142.62</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_984_eecd--PeerGroupTotalShareholderRtnAmt_pp2d_c20200101__20201231_fKDgp_zOBDwEqwIo1g" style="text-align: right">158.17</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left; vertical-align: top">$</td><td style="text-align: right">2.7 Billion</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left; vertical-align: top">$</td><td style="text-align: right; padding-right: 3pt">6.2 Billion</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; padding-left: 3pt">2019</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">N/A</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_981_eecd--PeoTotalCompAmt_c20190101__20191231__ecd--IndividualAxis__custom--JeffreyLeidenMember_fKDIp_z3SA7dJcZxv9" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">18,789,985</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">N/A</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_982_eecd--PeoActuallyPaidCompAmt_c20190101__20191231__ecd--IndividualAxis__custom--JeffreyLeidenMember_fKDIpKDQp_zFYDQezODXgl" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">37,124,321</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_982_eecd--NonPeoNeoAvgTotalCompAmt_c20190101__20191231_fKDUp_zPAHE28hhLk8" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">4,668,405</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_981_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20190101__20191231_fKDYp_ztUlbGIqpxkf" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">7,828,475</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98B_eecd--TotalShareholderRtnAmt_pp2d_c20190101__20191231_fKDcp_z8y1Hyh7ayNh" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">132.13</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98A_eecd--PeerGroupTotalShareholderRtnAmt_pp2d_c20190101__20191231_fKDgp_zWiufBLdt0ti" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">125.11</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; vertical-align: top">$</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">1.2 Billion</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; vertical-align: top">$</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: right; padding-right: 3pt">4.2 Billion</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F07_zVAHlT5jVGo4" style="display: none; padding-top: 3pt; width: 18pt; visibility: hidden">(1)</td> <td id="xdx_F1D_z8FTbPcKUqy6" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021, 2022 and 2023.</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F02_zq2KP1jrTRS7" style="display: none; padding-top: 3pt; visibility: hidden">(2)</td> <td id="xdx_F1A_zj1W0NFk6nV5" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Jeffrey Leiden, our CEO for 2019 and a portion of 2020 (until April 1, 2020).</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F02_zuLkFvoyKwBj" style="display: none; padding-top: 3pt; visibility: hidden">(3)</td> <td id="xdx_F14_zpukYfRcaZEd" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">The amounts in this column reflect the Compensation Actually Paid for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021, 2022 and 2023. The amounts in the following table reflect the adjustments (additions/deductions) to the Summary Compensation Table Total to determine Compensation Actually Paid. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; padding-top: 3pt; width: 18pt; visibility: hidden">(4)</td> <td style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">The amounts in this column reflect the Compensation Actually Paid for Jeffrey Leiden, our CEO for 2019 and a portion of 2020 (until April 1, 2020). The amounts in the following table reflect the adjustments (additions/deductions) to the Summary Compensation Table Total to determine Compensation Actually Paid. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F01_zRA8VA5m7Ze3" style="display: none; padding-top: 3pt; width: 18pt; visibility: hidden">(5)</td> <td id="xdx_F17_zpo2Xs3DIgmd" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">This column reflects the average of the amounts reported in the “Total” column of the Summary Compensation Table for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The NEOs included for purposes of computing the amounts in this column were as follows: for 2023 and 2022, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Dr. Leiden; for 2021, Mr. Wagner, Mr. Arbuckle, Dr. Leiden, and Nia Tatsis; for 2020, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Michael Parini; and for 2019, Ms. Kewalramani, Mr. Wagner, Mr. Arbuckle, Amit Sachdev, Paul Silva and Ian Smith.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; font-size: 8pt; width: 18pt; visibility: hidden">(6)</td> <td style="display: none; font-size: 8pt; text-align: justify; visibility: hidden">This column reflects the average of the Compensation Actually Paid for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The amounts in the following table reflect the adjustments to the Summary Compensation Table Total to determine Compensation Actually Paid. The NEOs included for purposes of computing the amounts in this column are listed in footnote (5) above. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F0A_zUpsfZlW7rR5" style="display: none; padding-top: 3pt; width: 18pt; visibility: hidden">(7)</td> <td id="xdx_F1D_zeG3Q8NSOgqj" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">This column represents our cumulative total shareholder return (“TSR”) under SEC rules from December 31, 2018, the last trading day before the start of 2019, through the last trading day for the applicable fiscal year in the table. TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our share price at the end and the beginning of the measurement period by our share price at the beginning of the measurement period.</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F03_zHYnKOrKN73f" style="display: none; padding-top: 3pt; visibility: hidden">(8)</td> <td id="xdx_F1D_zOIXY80oaEg7" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">This column represents the TSR of the NBI, our selected peer group, which is the same peer group used for purposes of Item 201(e) of Regulation S-K from December 31, 2018, the last trading day before the start of 2019, through the last trading day for the applicable fiscal year in the table, assuming reinvestment of dividends and weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated.</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F07_zNScyAGT9x5c" style="display: none; padding-top: 3pt; visibility: hidden">(9)</td> <td id="xdx_F18_zCPWJNGKglM" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">This column reflects net income as reported for each year in our Annual Report on Form 10-K.</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F03_zEmnRzTxXT49" style="display: none; padding-top: 3pt; visibility: hidden">(10)</td> <td id="xdx_F16_zECVh24g2Uo1" style="display: none; text-align: justify; padding-top: 3pt; visibility: hidden">This column reflects net product revenue as reported for each year in our Annual Report on Form 10-K. For purposes of the table above, we have selected net product revenue as the financial performance measure representing the most important financial performance measure used to link executive compensation actually paid to our financial performance in the most recently completed fiscal year. Please the Compensation Discussion and Analysis section beginning on page 50 of this proxy statement for additional information.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">(1)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021, 2022 and 2023.</td></tr> <tr style="vertical-align: top"> <td style="padding-top: 3pt">(2)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Jeffrey Leiden, our CEO for 2019 and a portion of 2020 (until April 1, 2020).</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="padding-top: 3pt; width: 18pt">(3)</td> <td style="text-align: justify; padding-top: 3pt">The amounts in this column reflect the Compensation Actually Paid for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021, 2022 and 2023. The amounts in the following table reflect the adjustments (additions/deductions) to the Summary Compensation Table Total to determine Compensation Actually Paid. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans.</td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_30B_zmsV0k9RmlAe" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 97%; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: left; padding-left: 3pt">Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Summary Compensation Table Total</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Deducted from Grant Date Value of Annual Equity</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for the Fair Value of Awards Granted During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for Awards Granted & Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Add/ Deducted for Awards that Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End(a)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Compensation Actually Paid</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="width: 36%; text-align: left; padding-left: 3pt">2023</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_989_eecd--PeoTotalCompAmt_pp0p0_c20230101__20231231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zUhuKpbvjVVl" style="width: 5%; text-align: right">20,594,441</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zvJvtpWjqQQf" style="width: 5%; text-align: right">(15,001,894)</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zf10bPXkivac" style="width: 5%; text-align: right">24,692,933</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_989_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zis2EmegB4vh" style="width: 5%; text-align: right">—</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zXyvzWApbh44" style="width: 5%; text-align: right">272,767</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zBUXhmSV88u8" style="width: 5%; text-align: right">13,643,927</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_988_eecd--PeoActuallyPaidCompAmt_pp0p0_c20230101__20231231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zW87fuuAKepb" style="width: 5%; text-align: right; padding-right: 3pt">44,202,174</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-bottom: 1px; padding-left: 3pt">2022</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--PeoTotalCompAmt_pp0p0_c20220101__20221231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zcFOPjzVYIFd" style="text-align: right">15,864,497</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98D_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zoXPq7L0IL6e" style="text-align: right">(10,640,784)</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98E_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zBMxrRIOp0Bh" style="text-align: right">16,817,103</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zcfbpIZ34iph" style="text-align: right">—</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_981_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zSFwkMJg51Wf" style="text-align: right">768,712</td><td style="padding-bottom: 1px; text-align: left"> </td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_986_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_z3oY8JGu768b" style="text-align: right">6,719,561</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_pp0p0_c20220101__20221231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zdDtRsuKw9Og" style="text-align: right; padding-right: 3pt">29,529,089</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="text-align: left; padding-left: 3pt">2021</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98E_eecd--PeoTotalCompAmt_pp0p0_c20210101__20211231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zXiCERGNiUN" style="text-align: right">15,198,856</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98A_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zJ11Obe9p685" style="text-align: right">(10,924,599)</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zcOE9rIxfJNk" style="text-align: right">14,344,492</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_989_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_ze0XC6leRvjj" style="text-align: right">—</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_z48APlfZBxi7" style="text-align: right">(659,323)</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zJ7sphCc1Bpg" style="text-align: right">382,063</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_pp0p0_c20210101__20211231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zPqsFxYuUeK" style="text-align: right; padding-right: 3pt">18,341,489</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; padding-bottom: 1px; padding-left: 3pt">2020</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98D_eecd--PeoTotalCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zCZ2kpgw6cK9" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">9,111,359</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_984_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zVR5SZyFEYjc" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">(5,250,411)</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zlAfs98UCgT1" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">6,587,268</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zEvCPnKZK5Mf" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">—</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_987_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zGVXz4Dq4VOb" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">345,685</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98A_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zpkwE9ntZDYk" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">1,378,553</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_980_eecd--PeoActuallyPaidCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zkzLhadqUHG3" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right; padding-right: 3pt">12,172,454</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt"> </td> <td id="xdx_F03_z9x27jo30jCh" style="width: 18pt; padding-top: 3pt">(a)</td> <td id="xdx_F1B_zyhjIdjC1Tgi" style="text-align: justify; padding-top: 3pt">Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2023, 2022, 2021, 2020 and 2019; and, the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020, respectively; the non-financial PSU award for 2021 was valued at 100%, 50% and 50% as of December 31, 2023, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 50% and 0% as of December 31, 2023 and 2022, respectively; the non-financial PSU award for 2023 was valued at 50% as of December 31, 2023.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">(4)</td> <td style="text-align: justify; padding-top: 3pt">The amounts in this column reflect the Compensation Actually Paid for Jeffrey Leiden, our CEO for 2019 and a portion of 2020 (until April 1, 2020). The amounts in the following table reflect the adjustments (additions/deductions) to the Summary Compensation Table Total to determine Compensation Actually Paid. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans.</td></tr> </table> <div id="xdx_C07_gL2ATPCFTB-AWWEWPN_zmsffWS88PH7"> <table cellpadding="0" cellspacing="0" id="xdx_308_zKucmF0i4jfk" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 97%; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: left; padding-left: 3pt">Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Summary Compensation Table Total</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Deducted from Grant Date Value of Annual Equity</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for the Fair Value of Awards Granted During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for Awards Granted & Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Add/ Deducted for Awards that Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End(a)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Compensation Actually Paid</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="width: 37%; text-align: left; padding-left: 3pt">2020</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98F_eecd--PeoTotalCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--JeffreyLeidenMember_zlqfol6V0Q06" style="width: 5%; text-align: right">16,473,245</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98C_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zyItBF8YZv3d" style="width: 5%; text-align: right">(13,335,168)</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zrHvPiZK0392" style="width: 5%; text-align: right">9,294,661</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_983_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zenHOBevdDrd" style="width: 5%; text-align: right">7,362,423</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_986_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zHzL78R7amCa" style="width: 5%; text-align: right">5,724,395</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98B_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_z4ieeYdWOPmk" style="width: 5%; text-align: right">5,800,268</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_981_eecd--PeoActuallyPaidCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--JeffreyLeidenMember_zEkCq6DmhLLh" style="width: 5%; text-align: right; padding-right: 3pt">31,319,824</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; padding-bottom: 1px; padding-left: 3pt">2019</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98B_eecd--PeoTotalCompAmt_pp0p0_c20190101__20191231__ecd--IndividualAxis__custom--JeffreyLeidenMember_z8jfPtz34dUe" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">18,789,985</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zyUat5Lb4HI2" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">(13,906,720)</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_984_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zepyP56CvBc2" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">17,220,100</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_986_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_ziYMqJFFZw2e" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">509,338</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zxdhchzG7ZL" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">4,201,319</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98D_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zeYri3a1Rhn8" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">10,310,299</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98A_eecd--PeoActuallyPaidCompAmt_pp0p0_c20190101__20191231__ecd--IndividualAxis__custom--JeffreyLeidenMember_zORY7N5GBmX5" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right; padding-right: 3pt">37,124,321</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt"> </td> <td id="xdx_F0E_zm8IBWELd0ja" style="width: 18pt; padding-top: 3pt">(a)</td> <td id="xdx_F15_zQbXvBJSYAJ7" style="text-align: justify; padding-top: 3pt">Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2020, 2019 and 2018; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019 and 2018; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 100% and 50% as of December 31, 2020 and 2019, respectively; the non-financial PSU award for 2020 was valued at 50% as of December 31, 2020.</td></tr> </table> </div> <div id="xdx_C08_gL2NEOFTB-XVZPK_zDwf2cIca5a6"> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">(5)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects the average of the amounts reported in the “Total” column of the Summary Compensation Table for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The NEOs included for purposes of computing the amounts in this column were as follows: for 2023 and 2022, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Dr. Leiden; for 2021, Mr. Wagner, Mr. Arbuckle, Dr. Leiden, and Nia Tatsis; for 2020, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Michael Parini; and for 2019, Ms. Kewalramani, Mr. Wagner, Mr. Arbuckle, Amit Sachdev, Paul Silva and Ian Smith.</td></tr> </table> </div> <div style="border-bottom: Silver 4px solid; margin-bottom: 6pt"> </div> <div style="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"></div> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; font-size: 8pt">(6)</td> <td style="font-size: 8pt; text-align: justify">This column reflects the average of the Compensation Actually Paid for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The amounts in the following table reflect the adjustments to the Summary Compensation Table Total to determine Compensation Actually Paid. The NEOs included for purposes of computing the amounts in this column are listed in footnote (5) above. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans.</td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_30B_zT3tSWI9LXOk" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 97%; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: left; padding-left: 3pt">Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Summary Compensation Table Total</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Deducted from Grant Date Value of Annual Equity</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for the Fair Value of Awards Granted During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for Awards Granted & Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Add/ Deducted for Awards that Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End(a)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Compensation Actually Paid</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="width: 36%; text-align: left; padding-left: 3pt">2023</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_981_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_zbb4BFUpgeGg" style="width: 5%; text-align: right">7,376,771</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zJiqc141pvC1" style="width: 5%; text-align: right">(5,590,153)</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98C_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_z1ly6PHGFsz5" style="width: 5%; text-align: right">8,606,944</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zCvW9H3shGOf" style="width: 5%; text-align: right">812,533</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_985_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zfsc8UqPZp59" style="width: 5%; text-align: right">236,286</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_982_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____z6wwMzSNT4N2" style="width: 5%; text-align: right">6,661,784</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_z7nPTYOFs6ll" style="width: 5%; text-align: right; padding-right: 3pt">18,104,165</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-left: 3pt">2022</td><td> </td> <td style="text-align: left">$</td><td id="xdx_982_eecd--NonPeoNeoAvgTotalCompAmt_c20220101__20221231_zrvzLCho19q2" style="text-align: right">8,982,257</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zfQ9VKjMpaW7" style="text-align: right">(7,261,199)</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98B_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zRFX60AZeCv" style="text-align: right">9,489,852</td><td> </td> <td style="text-align: left">$</td><td id="xdx_985_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zDLJYGAfaHLc" style="text-align: right">1,062,531</td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zr8uRxdg2Dcd" style="text-align: right">538,093</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_980_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____zVPXSVmz1vMk" style="text-align: right">5,451,796</td><td> </td> <td style="text-align: left">$</td><td id="xdx_981_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20220101__20221231_z8cbz8hUDxh4" style="text-align: right; padding-right: 3pt">18,263,330</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="text-align: left; padding-left: 3pt">2021</td><td> </td> <td style="text-align: left">$</td><td id="xdx_988_eecd--NonPeoNeoAvgTotalCompAmt_c20210101__20211231_zDXYblL18oyl" style="text-align: right">7,193,835</td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zka6uwFny8w2" style="text-align: right">(5,687,759)</td><td> </td> <td style="text-align: left">$</td><td id="xdx_986_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_z7lEKgC0UTFe" style="text-align: right">6,319,320</td><td> </td> <td style="text-align: left">$</td><td id="xdx_981_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zAopeZRDxxo" style="text-align: right">1,125,037</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zlTToL1UR4t4" style="text-align: right">(778,741)</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____zTKEnp7FeZJ5" style="text-align: right">797,359</td><td> </td> <td style="text-align: left">$</td><td id="xdx_984_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20210101__20211231_zGdMOmHYdKx" style="text-align: right; padding-right: 3pt">8,969,051</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-left: 3pt">2020</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--NonPeoNeoAvgTotalCompAmt_c20200101__20201231_znk3XNaIXdjg" style="text-align: right">6,697,408</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98E_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zZnfM7Q3nDKl" style="text-align: right">(4,812,998)</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_z07n6boDBoTe" style="text-align: right">6,038,487</td><td> </td> <td style="text-align: left">$</td><td id="xdx_985_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zKisKL05RUjg" style="text-align: right">—</td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zTCkZAJBMiG6" style="text-align: right">1,048,920</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_987_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____z9ALijkoxcC7" style="text-align: right">1,612,567</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20200101__20201231_zyRwMVJ3nN49" style="text-align: right; padding-right: 3pt">10,584,384</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; padding-left: 3pt">2019</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgTotalCompAmt_c20190101__20191231_zmAoFpnBwX0h" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">4,668,405</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98F_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zkfv9rdXLwc4" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">(3,093,700)</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_984_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zz6fPBjA3i6l" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">4,011,590</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98D_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zipLCqTt1RG9" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">103,204</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_987_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zZnTF9Q8Zr45" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">866,837</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98E_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____zlSeBPEWyat" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">1,272,139</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20190101__20191231_zvyVBRy6ScN3" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right; padding-right: 3pt">7,828,475</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt"> </td> <td id="xdx_F0D_zEP2rMAKZEXk" style="width: 18pt; padding-top: 3pt">(a)</td> <td id="xdx_F16_zxosFRrSYPqh" style="text-align: justify; padding-top: 3pt">Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2023, 2022, 2021, 2020, 2019, and 2018; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019 and 2018; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 200%, 100% and 50% as of December 31, 2021, 2020 and 2019; the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020; the non-financial PSU award for 2021 was valued at 100%, 50% and 50% as of December 31, 2023, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 50% and 0% as of December 31, 2023 and 2022, respectively; the non-financial PSU award for 2023 was valued at 50% as of December 31, 2023.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">(7)</td> <td style="text-align: justify; padding-top: 3pt">This column represents our cumulative total shareholder return (“TSR”) under SEC rules from December 31, 2018, the last trading day before the start of 2019, through the last trading day for the applicable fiscal year in the table. TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our share price at the end and the beginning of the measurement period by our share price at the beginning of the measurement period.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="padding-top: 3pt; width: 18pt">(8)</td> <td style="text-align: justify; padding-top: 3pt">This column represents the TSR of the NBI, our selected peer group, which is the same peer group used for purposes of Item 201(e) of Regulation S-K from December 31, 2018, the last trading day before the start of 2019, through the last trading day for the applicable fiscal year in the table, assuming reinvestment of dividends and weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="padding-top: 3pt; width: 18pt">(9)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects net income as reported for each year in our Annual Report on Form 10-K.</td></tr> <tr style="vertical-align: top"> <td style="padding-top: 3pt">(10)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects net product revenue as reported for each year in our Annual Report on Form 10-K. For purposes of the table above, we have selected net product revenue as the financial performance measure representing the most important financial performance measure used to link executive compensation actually paid to our financial performance in the most recently completed fiscal year. Please the Compensation Discussion and Analysis section beginning on page 50 of this proxy statement for additional information.</td></tr> </table> 20594441 44202174 7376771 18104165 245.54 148.72

3600000000

9900000000 15864497 29529089 8982257 18263330 174.27 142.19

3300000000

8900000000 15198856 18341489 7193835 8969051 132.52 158.20

2300000000

7600000000 9111359 16473245 12172454 31319824 6697408 10584384 142.62 158.17

2700000000

6200000000 18789985 37124321 4668405 7828475 132.13 125.11

1200000000

4200000000 <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">(1)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021, 2022 and 2023.</td></tr> <tr style="vertical-align: top"> <td style="padding-top: 3pt">(2)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Jeffrey Leiden, our CEO for 2019 and a portion of 2020 (until April 1, 2020).</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">(5)</td> <td style="text-align: justify; padding-top: 3pt">This column reflects the average of the amounts reported in the “Total” column of the Summary Compensation Table for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The NEOs included for purposes of computing the amounts in this column were as follows: for 2023 and 2022, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Dr. Leiden; for 2021, Mr. Wagner, Mr. Arbuckle, Dr. Leiden, and Nia Tatsis; for 2020, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Michael Parini; and for 2019, Ms. Kewalramani, Mr. Wagner, Mr. Arbuckle, Amit Sachdev, Paul Silva and Ian Smith.</td></tr> </table> Reshma Kewalramani Reshma Kewalramani Reshma Kewalramani Reshma Kewalramani Jeffrey Leiden Jeffrey Leiden <table cellpadding="0" cellspacing="0" id="xdx_30B_zmsV0k9RmlAe" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 97%; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: left; padding-left: 3pt">Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Summary Compensation Table Total</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Deducted from Grant Date Value of Annual Equity</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for the Fair Value of Awards Granted During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for Awards Granted & Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Add/ Deducted for Awards that Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End(a)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Compensation Actually Paid</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="width: 36%; text-align: left; padding-left: 3pt">2023</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_989_eecd--PeoTotalCompAmt_pp0p0_c20230101__20231231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zUhuKpbvjVVl" style="width: 5%; text-align: right">20,594,441</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zvJvtpWjqQQf" style="width: 5%; text-align: right">(15,001,894)</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zf10bPXkivac" style="width: 5%; text-align: right">24,692,933</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_989_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zis2EmegB4vh" style="width: 5%; text-align: right">—</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zXyvzWApbh44" style="width: 5%; text-align: right">272,767</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zBUXhmSV88u8" style="width: 5%; text-align: right">13,643,927</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_988_eecd--PeoActuallyPaidCompAmt_pp0p0_c20230101__20231231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zW87fuuAKepb" style="width: 5%; text-align: right; padding-right: 3pt">44,202,174</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-bottom: 1px; padding-left: 3pt">2022</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--PeoTotalCompAmt_pp0p0_c20220101__20221231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zcFOPjzVYIFd" style="text-align: right">15,864,497</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98D_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zoXPq7L0IL6e" style="text-align: right">(10,640,784)</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98E_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zBMxrRIOp0Bh" style="text-align: right">16,817,103</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zcfbpIZ34iph" style="text-align: right">—</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_981_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zSFwkMJg51Wf" style="text-align: right">768,712</td><td style="padding-bottom: 1px; text-align: left"> </td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_986_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_z3oY8JGu768b" style="text-align: right">6,719,561</td><td style="padding-bottom: 1px"> </td> <td style="text-align: left">$</td><td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_pp0p0_c20220101__20221231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zdDtRsuKw9Og" style="text-align: right; padding-right: 3pt">29,529,089</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="text-align: left; padding-left: 3pt">2021</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98E_eecd--PeoTotalCompAmt_pp0p0_c20210101__20211231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zXiCERGNiUN" style="text-align: right">15,198,856</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98A_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zJ11Obe9p685" style="text-align: right">(10,924,599)</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zcOE9rIxfJNk" style="text-align: right">14,344,492</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_989_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_ze0XC6leRvjj" style="text-align: right">—</td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_z48APlfZBxi7" style="text-align: right">(659,323)</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zJ7sphCc1Bpg" style="text-align: right">382,063</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_pp0p0_c20210101__20211231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zPqsFxYuUeK" style="text-align: right; padding-right: 3pt">18,341,489</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; padding-bottom: 1px; padding-left: 3pt">2020</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98D_eecd--PeoTotalCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zCZ2kpgw6cK9" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">9,111,359</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_984_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zVR5SZyFEYjc" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">(5,250,411)</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98F_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zlAfs98UCgT1" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">6,587,268</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zEvCPnKZK5Mf" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">—</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_987_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zGVXz4Dq4VOb" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">345,685</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98A_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--ReshmaKewalramaniMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zpkwE9ntZDYk" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">1,378,553</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_980_eecd--PeoActuallyPaidCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--ReshmaKewalramaniMember_zkzLhadqUHG3" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right; padding-right: 3pt">12,172,454</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt"> </td> <td id="xdx_F03_z9x27jo30jCh" style="width: 18pt; padding-top: 3pt">(a)</td> <td id="xdx_F1B_zyhjIdjC1Tgi" style="text-align: justify; padding-top: 3pt">Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2023, 2022, 2021, 2020 and 2019; and, the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020, respectively; the non-financial PSU award for 2021 was valued at 100%, 50% and 50% as of December 31, 2023, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 50% and 0% as of December 31, 2023 and 2022, respectively; the non-financial PSU award for 2023 was valued at 50% as of December 31, 2023.</td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_308_zKucmF0i4jfk" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 97%; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: left; padding-left: 3pt">Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Summary Compensation Table Total</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Deducted from Grant Date Value of Annual Equity</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for the Fair Value of Awards Granted During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for Awards Granted & Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Add/ Deducted for Awards that Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End(a)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Compensation Actually Paid</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="width: 37%; text-align: left; padding-left: 3pt">2020</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98F_eecd--PeoTotalCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--JeffreyLeidenMember_zlqfol6V0Q06" style="width: 5%; text-align: right">16,473,245</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98C_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zyItBF8YZv3d" style="width: 5%; text-align: right">(13,335,168)</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_985_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zrHvPiZK0392" style="width: 5%; text-align: right">9,294,661</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_983_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zenHOBevdDrd" style="width: 5%; text-align: right">7,362,423</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_986_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zHzL78R7amCa" style="width: 5%; text-align: right">5,724,395</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98B_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_z4ieeYdWOPmk" style="width: 5%; text-align: right">5,800,268</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_981_eecd--PeoActuallyPaidCompAmt_pp0p0_c20200101__20201231__ecd--IndividualAxis__custom--JeffreyLeidenMember_zEkCq6DmhLLh" style="width: 5%; text-align: right; padding-right: 3pt">31,319,824</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; padding-bottom: 1px; padding-left: 3pt">2019</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98B_eecd--PeoTotalCompAmt_pp0p0_c20190101__20191231__ecd--IndividualAxis__custom--JeffreyLeidenMember_z8jfPtz34dUe" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">18,789,985</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zyUat5Lb4HI2" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">(13,906,720)</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_984_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zepyP56CvBc2" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">17,220,100</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_986_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_ziYMqJFFZw2e" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">509,338</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_988_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zxdhchzG7ZL" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">4,201,319</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_98D_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--IndividualAxis__custom--JeffreyLeidenMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEp_zeYri3a1Rhn8" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">10,310,299</td><td style="border-bottom: rgb(67,18,99) 2px solid; padding-bottom: 1px"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98A_eecd--PeoActuallyPaidCompAmt_pp0p0_c20190101__20191231__ecd--IndividualAxis__custom--JeffreyLeidenMember_zORY7N5GBmX5" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right; padding-right: 3pt">37,124,321</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt"> </td> <td id="xdx_F0E_zm8IBWELd0ja" style="width: 18pt; padding-top: 3pt">(a)</td> <td id="xdx_F15_zQbXvBJSYAJ7" style="text-align: justify; padding-top: 3pt">Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2020, 2019 and 2018; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019 and 2018; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 100% and 50% as of December 31, 2020 and 2019, respectively; the non-financial PSU award for 2020 was valued at 50% as of December 31, 2020.</td></tr> </table> 20594441 -15001894 24692933 272767 13643927 44202174 15864497 -10640784 16817103 768712 6719561 29529089 15198856 -10924599 14344492 -659323 382063 18341489 9111359 -5250411 6587268 345685 1378553 12172454 16473245 -13335168 9294661 7362423 5724395 5800268 31319824 18789985 -13906720 17220100 509338 4201319 10310299 37124321 <table cellpadding="0" cellspacing="0" id="xdx_30B_zT3tSWI9LXOk" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 97%; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: left; padding-left: 3pt">Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Summary Compensation Table Total</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Deducted from Grant Date Value of Annual Equity</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for the Fair Value of Awards Granted During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added for Awards Granted & Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Add/ Deducted for Awards that Vested During Fiscal Year</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right">Amounts Added/ Deducted for the Change in Fair Value of Awards Outstanding at Fiscal Year End(a)</td><td style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263"> </td> <td colspan="2" style="border-bottom: rgb(67,18,99) 2px solid; white-space: nowrap; color: #431263; text-align: right; padding-right: 3pt">Compensation Actually Paid</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="width: 36%; text-align: left; padding-left: 3pt">2023</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_981_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_zbb4BFUpgeGg" style="width: 5%; text-align: right">7,376,771</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zJiqc141pvC1" style="width: 5%; text-align: right">(5,590,153)</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98C_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_z1ly6PHGFsz5" style="width: 5%; text-align: right">8,606,944</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zCvW9H3shGOf" style="width: 5%; text-align: right">812,533</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_985_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zfsc8UqPZp59" style="width: 5%; text-align: right">236,286</td><td style="width: 1%; text-align: left"> </td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_982_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____z6wwMzSNT4N2" style="width: 5%; text-align: right">6,661,784</td><td style="width: 3%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_z7nPTYOFs6ll" style="width: 5%; text-align: right; padding-right: 3pt">18,104,165</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-left: 3pt">2022</td><td> </td> <td style="text-align: left">$</td><td id="xdx_982_eecd--NonPeoNeoAvgTotalCompAmt_c20220101__20221231_zrvzLCho19q2" style="text-align: right">8,982,257</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zfQ9VKjMpaW7" style="text-align: right">(7,261,199)</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98B_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zRFX60AZeCv" style="text-align: right">9,489,852</td><td> </td> <td style="text-align: left">$</td><td id="xdx_985_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zDLJYGAfaHLc" style="text-align: right">1,062,531</td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zr8uRxdg2Dcd" style="text-align: right">538,093</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_980_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____zVPXSVmz1vMk" style="text-align: right">5,451,796</td><td> </td> <td style="text-align: left">$</td><td id="xdx_981_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20220101__20221231_z8cbz8hUDxh4" style="text-align: right; padding-right: 3pt">18,263,330</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="text-align: left; padding-left: 3pt">2021</td><td> </td> <td style="text-align: left">$</td><td id="xdx_988_eecd--NonPeoNeoAvgTotalCompAmt_c20210101__20211231_zDXYblL18oyl" style="text-align: right">7,193,835</td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zka6uwFny8w2" style="text-align: right">(5,687,759)</td><td> </td> <td style="text-align: left">$</td><td id="xdx_986_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_z7lEKgC0UTFe" style="text-align: right">6,319,320</td><td> </td> <td style="text-align: left">$</td><td id="xdx_981_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zAopeZRDxxo" style="text-align: right">1,125,037</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zlTToL1UR4t4" style="text-align: right">(778,741)</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____zTKEnp7FeZJ5" style="text-align: right">797,359</td><td> </td> <td style="text-align: left">$</td><td id="xdx_984_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20210101__20211231_zGdMOmHYdKx" style="text-align: right; padding-right: 3pt">8,969,051</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: left; padding-left: 3pt">2020</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98D_eecd--NonPeoNeoAvgTotalCompAmt_c20200101__20201231_znk3XNaIXdjg" style="text-align: right">6,697,408</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98E_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zZnfM7Q3nDKl" style="text-align: right">(4,812,998)</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98A_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_z07n6boDBoTe" style="text-align: right">6,038,487</td><td> </td> <td style="text-align: left">$</td><td id="xdx_985_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zKisKL05RUjg" style="text-align: right">—</td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zTCkZAJBMiG6" style="text-align: right">1,048,920</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_987_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____z9ALijkoxcC7" style="text-align: right">1,612,567</td><td> </td> <td style="text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20200101__20201231_zyRwMVJ3nN49" style="text-align: right; padding-right: 3pt">10,584,384</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left; padding-left: 3pt">2019</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgTotalCompAmt_c20190101__20191231_zmAoFpnBwX0h" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">4,668,405</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98F_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsDeductedFromGrantDateValueOfAnnualEquityMember_zkfv9rdXLwc4" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">(3,093,700)</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_984_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForTheFairValueOfGrantedDuringFiscalYearMember_zz6fPBjA3i6l" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">4,011,590</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98D_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedForAwardsGrantedAndVestedDuringFiscalYearMember_zipLCqTt1RG9" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">103,204</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_987_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddDeductedForAwardsThatVestedDuringFiscalYearMember_zZnTF9Q8Zr45" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">866,837</td><td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98E_eecd--AdjToCompAmt_c20190101__20191231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AmountsAddedDeductedForTheChangeInFairOfAwardsOutstandingAtFiscalYearEndMember_fKGEuKQ_____zlSeBPEWyat" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right">1,272,139</td><td style="border-bottom: rgb(67,18,99) 2px solid"> </td> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20190101__20191231_zvyVBRy6ScN3" style="border-bottom: rgb(67,18,99) 2px solid; text-align: right; padding-right: 3pt">7,828,475</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt"> </td> <td id="xdx_F0D_zEP2rMAKZEXk" style="width: 18pt; padding-top: 3pt">(a)</td> <td id="xdx_F16_zxosFRrSYPqh" style="text-align: justify; padding-top: 3pt">Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2023, 2022, 2021, 2020, 2019, and 2018; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019 and 2018; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 200%, 100% and 50% as of December 31, 2021, 2020 and 2019; the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020; the non-financial PSU award for 2021 was valued at 100%, 50% and 50% as of December 31, 2023, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 50% and 0% as of December 31, 2023 and 2022, respectively; the non-financial PSU award for 2023 was valued at 50% as of December 31, 2023.</td></tr> </table> 7376771 -5590153 8606944 812533 236286 6661784 18104165 8982257 -7261199 9489852 1062531 538093 5451796 18263330 7193835 -5687759 6319320 1125037 -778741 797359 8969051 6697408 -4812998 6038487 1048920 1612567 10584384 4668405 -3093700 4011590 103204 866837 1272139 7828475 <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="padding-top: 3pt; width: 18pt">(8)</td> <td style="text-align: justify; padding-top: 3pt">This column represents the TSR of the NBI, our selected peer group, which is the same peer group used for purposes of Item 201(e) of Regulation S-K from December 31, 2018, the last trading day before the start of 2019, through the last trading day for the applicable fiscal year in the table, assuming reinvestment of dividends and weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated.</td></tr> </table> net product revenue <h6 id="xdx_846_eecd--TotalShareholderRtnVsPeerGroupTextBlock_dU_zhrGkfPpwROj" style="font: 12pt Arial, Helvetica, Sans-Serif; margin: 0pt; color: #431263">Compensation Actually Paid vs TSR (and TSR vs Peer Group TSR)</h6> <img alt="" src="lvrtx2024x86x1.jpg"/> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt">(1)</td> <td style="text-align: justify">2020 Compensation Actually Paid represented here reflects 2020 compensation of Reshma Kewalramani, our current CEO, and excludes 2020 compensation paid to Jeffrey Leiden, our former CEO.</td></tr> </table> <h6 id="xdx_846_eecd--TotalShareholderRtnVsPeerGroupTextBlock_dU_zhrGkfPpwROj" style="font: 12pt Arial, Helvetica, Sans-Serif; margin: 0pt; color: #431263">Compensation Actually Paid vs TSR (and TSR vs Peer Group TSR)</h6> <img alt="" src="lvrtx2024x86x1.jpg"/> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt">(1)</td> <td style="text-align: justify">2020 Compensation Actually Paid represented here reflects 2020 compensation of Reshma Kewalramani, our current CEO, and excludes 2020 compensation paid to Jeffrey Leiden, our former CEO.</td></tr> </table> <h6 id="xdx_80D_eecd--CompActuallyPaidVsNetIncomeTextBlock_dU_zwBSzl8Iu4N8" style="font: 12pt Arial, Helvetica, Sans-Serif; margin: 0pt; color: #431263">Compensation Actually Paid vs Net Income</h6> <img alt="" src="lvrtx2024x87x1.jpg"/> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; font-size: 8pt">(1)</td> <td style="font-size: 8pt; text-align: justify">2020 Compensation Actually Paid represented here reflects 2020 compensation of Reshma Kewalramani, our current CEO, and excludes 2020 compensation paid to Jeffrey Leiden, our former CEO.</td></tr> </table> <h6 id="xdx_801_eecd--CompActuallyPaidVsCoSelectedMeasureTextBlock_dU_zUoo6kYpP4tb" style="font: 12pt Arial, Helvetica, Sans-Serif; margin: 0pt; color: #431263">Compensation Actually Paid vs Net Product Revenue</h6> <img alt="" src="lvrtx2024x87x2.jpg"/> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; font-size: 8pt">(1)</td> <td style="font-size: 8pt; text-align: justify">2020 Compensation Actually Paid represented here reflects 2020 compensation of Reshma Kewalramani, our current CEO, and excludes 2020 compensation paid to Jeffrey Leiden, our former CEO.</td></tr> </table> <h6 id="xdx_803_eecd--TabularListTableTextBlock_dU_zIFwNN0N6h83" style="font: 12pt Arial, Helvetica, Sans-Serif; margin: 0pt; color: #431263">List of Performance Measures</h6> The tabular list below includes the three financial and non-financial performance measures that represent the most important performance measures used to link compensation actually paid to company performance in 2023. The performance measures included in this list are not ranked by relative importance. <table cellpadding="0" cellspacing="0" id="xdx_306_zkknSRwchpOc" style="font: 9pt Arial, Helvetica, Sans-Serif; margin-left: auto; width: 70%; margin-right: auto" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="width: 100%; text-align: center; padding-bottom: 2pt">Performance Measures Used to Link Executive Compensation Actually Paid to Company Performance for the Most Recently Completed Fiscal Year</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="border-top: rgb(67,18,99) 2px solid; text-align: center; padding-top: 2pt; padding-bottom: 2pt">Net Product Revenue</td></tr> <tr style="vertical-align: bottom"> <td style="text-align: center; padding-top: 2pt; padding-bottom: 2pt">Pipeline Progression(1)</td></tr> <tr style="vertical-align: bottom; background-color: rgb(231,231,232)"> <td style="border-bottom: rgb(67,18,99) 2px solid; text-align: center; padding-top: 2pt; padding-bottom: 2pt">Adjusted Non-GAAP EBITDA(2)</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td id="xdx_F02_zwifAHoKPOK4" style="width: 18pt; padding-bottom: 3pt">(1)</td> <td id="xdx_F15_zl9dO04d7bF8" style="text-align: justify; padding-bottom: 3pt">Pipeline progression is a non-financial performance measure used to link executive compensation to company performance, as described in Goals – Pipeline Growth (Late and Early Stage) and Performance Units Results Table.</td></tr> <tr style="vertical-align: top"> <td id="xdx_F06_z072Rn0lMpej">(2)</td> <td id="xdx_F1D_zS3WIYWHuhxk" style="text-align: justify">Adjusted non-GAAP EBITDA is a financial performance measure used to link compensation actually paid to company financial performance, as described in Goals – Financial Strength. We calculated adjusted non-GAAP EBITDA by excluding interest, taxes, depreciation and amortization expenses, as well as AIPR&D, from net income, as well as excluding each of our non-GAAP adjustments to pre-tax income included in our “Reconciliation of GAAP to Non-GAAP Net Income” in our quarterly earnings release filed on February 5, 2024 for the twelve months ended December 31, 2023.</td></tr> </table> Net Product Revenue Pipeline Progression Adjusted Non-GAAP EBITDA Adjusted non-GAAP EBITDA is a financial performance measure used to link compensation actually paid to company financial performance, as described in Goals – Financial Strength. We calculated adjusted non-GAAP EBITDA by excluding interest, taxes, depreciation and amortization expenses, as well as AIPR&D, from net income, as well as excluding each of our non-GAAP adjustments to pre-tax income included in our “Reconciliation of GAAP to Non-GAAP Net Income” in our quarterly earnings release filed on February 5, 2024 for the twelve months ended December 31, 2023. This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021, 2022 and 2023. The amounts in this column reflect the Compensation Actually Paid for Reshma Kewalramani, our CEO for a portion of 2020 (effective April 1, 2020), and for 2021, 2022 and 2023. The amounts in the following table reflect the adjustments (additions/deductions) to the Summary Compensation Table Total to determine Compensation Actually Paid. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans. This column reflects the amounts reported in the “Total” column of the Summary Compensation Table for Jeffrey Leiden, our CEO for 2019 and a portion of 2020 (until April 1, 2020). The amounts in this column reflect the Compensation Actually Paid for Jeffrey Leiden, our CEO for 2019 and a portion of 2020 (until April 1, 2020). The amounts in the following table reflect the adjustments (additions/deductions) to the Summary Compensation Table Total to determine Compensation Actually Paid. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans. This column reflects the average of the amounts reported in the “Total” column of the Summary Compensation Table for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The NEOs included for purposes of computing the amounts in this column were as follows: for 2023 and 2022, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Dr. Leiden; for 2021, Mr. Wagner, Mr. Arbuckle, Dr. Leiden, and Nia Tatsis; for 2020, Mr. Wagner, Dr. Altshuler, Mr. Arbuckle, and Michael Parini; and for 2019, Ms. Kewalramani, Mr. Wagner, Mr. Arbuckle, Amit Sachdev, Paul Silva and Ian Smith. This column reflects the average of the Compensation Actually Paid for our NEOs as a group (excluding our CEO or CEOs, in the case of 2020) for each of the periods presented. The amounts in the following table reflect the adjustments to the Summary Compensation Table Total to determine Compensation Actually Paid. The NEOs included for purposes of computing the amounts in this column are listed in footnote (5) above. Adjustments (additions/deductions) are not listed for Pension/Non-Qualified Deferred Compensation because we do not offer these plans. This column represents our cumulative total shareholder return (“TSR”) under SEC rules from December 31, 2018, the last trading day before the start of 2019, through the last trading day for the applicable fiscal year in the table. TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our share price at the end and the beginning of the measurement period by our share price at the beginning of the measurement period. This column represents the TSR of the NBI, our selected peer group, which is the same peer group used for purposes of Item 201(e) of Regulation S-K from December 31, 2018, the last trading day before the start of 2019, through the last trading day for the applicable fiscal year in the table, assuming reinvestment of dividends and weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated. This column reflects net income as reported for each year in our Annual Report on Form 10-K. This column reflects net product revenue as reported for each year in our Annual Report on Form 10-K. For purposes of the table above, we have selected net product revenue as the financial performance measure representing the most important financial performance measure used to link executive compensation actually paid to our financial performance in the most recently completed fiscal year. Please the section beginning on page 50 of this proxy statement for additional information. Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2023, 2022, 2021, 2020 and 2019; and, the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020, respectively; the non-financial PSU award for 2021 was valued at 100%, 50% and 50% as of December 31, 2023, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 50% and 0% as of December 31, 2023 and 2022, respectively; the non-financial PSU award for 2023 was valued at 50% as of December 31, 2023. Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2020, 2019 and 2018; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019 and 2018; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 100% and 50% as of December 31, 2020 and 2019, respectively; the non-financial PSU award for 2020 was valued at 50% as of December 31, 2020. Pursuant to applicable SEC rules, the fair values at the end of each fiscal year for the financial PSU awards were valued at 200% as of December 31, 2023, 2022, 2021, 2020, 2019, and 2018; and, the non-financial PSU award for 2016 was valued at 200% as of December 31, 2018; the non-financial PSU award for 2017 was valued at 200% as of December 31, 2019 and 2018; the non-financial PSU award for 2018 was valued at 200%, 100% and 100% as of December 31, 2020, 2019 and 2018, respectively; the non-financial PSU award for 2019 was valued at 200%, 100% and 50% as of December 31, 2021, 2020 and 2019; the non-financial PSU award for 2020 was valued at 200%, 50% and 50% as of December 31, 2022, 2021 and 2020; the non-financial PSU award for 2021 was valued at 100%, 50% and 50% as of December 31, 2023, 2022 and 2021, respectively; the non-financial PSU award for 2022 was valued at 50% and 0% as of December 31, 2023 and 2022, respectively; the non-financial PSU award for 2023 was valued at 50% as of December 31, 2023. Pipeline progression is a non-financial performance measure used to link executive compensation to company performance, as described in Goals – Pipeline Growth (Late and Early Stage) and Performance Units Results Table. Adjusted non-GAAP EBITDA is a financial performance measure used to link compensation actually paid to company financial performance, as described in Goals – Financial Strength. We calculated adjusted non-GAAP EBITDA by excluding interest, taxes, depreciation and amortization expenses, as well as AIPR&D, from net income, as well as excluding each of our non-GAAP adjustments to pre-tax income included in our “Reconciliation of GAAP to Non-GAAP Net Income” in our quarterly earnings release filed on February 5, 2024 for the twelve months ended December 31, 2023.