Supplemental disclosure of cash flow information: Supplemental Cash Flow Information [Abstract] Customer [Domain] Customer [Domain] Accrued expenses Deferred Tax Assets, Accrued Expenses and Other The tax effect as of the balance sheet date of the amount of the estimated future tax deductions arising from currently nondeductible expenses in accrued and other expenses, which can only be deducted for tax purposes when such items are actually incurred, and which can only be realized if sufficient tax-basis income is generated in future periods to enable the deduction to be taken. On Available-For-Sale Debt Securities AOCI, Accumulated Gain (Loss), Debt Securities, Available-for-sale, Parent [Member] Letter of Credit Letter of Credit [Member] State Current State and Local Tax Expense (Benefit) Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Leasehold improvements Leasehold Improvements [Member] Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Property and equipment, net Finance Lease, Right-Of-Use Asset, Gross Finance Lease, Right-Of-Use Asset, Gross Gross Amounts Presented Derivative Liability Security Exchange Name Security Exchange Name Fair Value Equity Securities, FV-NI, Current Cancelled ( in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Operating leases Operating Lease, Weighted Average Remaining Lease Term Foreign Currency Translation and Transactions Foreign Currency Transactions and Translations Policy [Policy Text Block] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Hedging Activities Derivatives, Policy [Policy Text Block] Accredo/Curascript Accredo/Curascript [Member] Accredo/Curascript [Member] Additional awards authorized for grant (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Net increase in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Expected stock price volatility (percent) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Acquired intangibles Deferred Tax Liabilities, Intangible Assets Total intrinsic value of stock options exercised Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value Schedule of Foreign Exchange Contracts, Condensed Consolidated Statements of Operations Reclassification out of Accumulated Other Comprehensive Income [Table Text Block] Exercise price, low end of range ( in usd per share) Share-based Payment Arrangement, Option, Exercise Price Range, Lower Range Limit Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Number of shares remaining for repurchases Stock Repurchase Program, Remaining Authorized Repurchase Amount Increases related to prior period tax positions Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions Net deferred tax assets Deferred Tax Assets, Net Operating leases Operating Lease, Weighted Average Discount Rate, Percent Schedule of Inventories by Type Schedule of Inventory, Current [Table Text Block] Antidilutive securities excluded from computation of earnings per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Revenues related to performance obligations Contract with Customer, Liability, Revenue Recognized Research and development expenses Research and Development Expense [Member] Total deferred tax assets Deferred Tax Assets, Net of Valuation Allowance Potential awards, percent of target shares, maximum Share-Based Compensation By Share-Based Payment Award, Award Percentage Of Target, Maximum Share-Based Compensation By Share-Based Payment Award, Award Percentage Of Target, Maximum Revenue from External Customer [Line Items] Revenue from External Customer [Line Items] Cash Flow Hedging Cash Flow Hedging [Member] Award Type [Domain] Award Type [Domain] Local Phone Number Local Phone Number Weighted-average Exercise Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] Money market funds Cash and Money Market Funds [Member] Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time. Stock options exercisable at end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number New Accounting Pronouncements or Change in Accounting Principle [Line Items] New Accounting Pronouncements or Change in Accounting Principle [Line Items] Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding Preferred Stock, Value, Issued Currency [Axis] Currency [Axis] Retained Earnings (Accumulated Deficit) Retained Earnings [Member] Area of real estate property (in square feet) Area of Real Estate Property Operating lease liabilities Deferred Tax Liabilities, Leasing Arrangements 2025 Finance Lease And Operating Lease, Liability, Payments, Due Year Four Finance Lease And Operating Lease, Liability, Payments, Due Year Four Collaborative arrangement research and development expenses Collaborative Arrangement, Research and Development Expenses Collaborative Arrangement, Research and Development Expenses Components of income (loss) before provision for (benefit from) income taxes Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest [Abstract] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Operating leases Leases, Operating [Abstract] Accounts receivable, net Increase (Decrease) in Accounts Receivable Collaborative arrangement, option payment Collaborative Arrangement, Option Payment Collaborative Arrangement, Option Payment Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Abstract] Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Common stock withheld for employee tax obligations (in shares) Share-based Payment Arrangement, Shares Withheld for Tax Withholding Obligation Payments on finance leases Financing cash flows from finance leases Finance Lease, Principal Payments Stock-based Compensation Expense Compensation Related Costs, Policy [Policy Text Block] Basic ( in usd per share) Basic net income per common share (in dollars per share) Earnings Per Share, Basic Operating loss carryforwards, subject to expiration Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration Sublease income Sublease Income Beginning of the period (in shares) End of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number ApolLo1 Bio, LLC ApolLo1 Bio, LLC [Member] ApolLo1 Bio, LLC Unrecognized Tax Benefits [Line Items] Unrecognized Tax Benefits [Line Items] Unrecognized Tax Benefits Cumulative Effect, Period of Adoption, Adjustment Cumulative Effect, Period of Adoption, Adjustment [Member] ESPP share issuances Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Commercial paper Commercial Paper [Member] Other non-cash items, net Other Noncash Income (Expense) Number of credit agreements Number Of Credit Agreements Number Of Credit Agreements Gross Amounts Recognized Derivative Asset, Fair Value, Gross Asset Number of pre-clinical stage programs Collaborative Arrangement, Right to License, Number Of Pre-Clinical Stage Programs Collaborative Arrangement, Right to License, Number Of Pre-Clinical Stage Programs Walgreen Co. Walgreen Co. [Member] Walgreen Co. [Member] Restricted cash and cash equivalents Restricted Cash and Cash Equivalents Property and equipment Deferred Tax Liabilities, Property, Plant and Equipment Non-financial performance shares Non-Financial Performance Shares [Member] Non-Financial Performance Shares Revenues and Property and Equipment by Location Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block] SYMDEKO/SYMKEVI SYMDEKO/SYMKEVI [Member] SYMDEKO/SYMKEVI [Member] Entity Voluntary Filers Entity Voluntary Filers CRISPR DMD/DM1 CRISPR DMD/DM1 [Member] CRISPR Therapeutics DMD/DM1 [Member] Issuance of common stock under benefit plans Stock Issued During Period, Value, Employee Benefit Plan Plan Name [Axis] Plan Name [Axis] Financial instruments carried at fair value (asset position): Assets, Fair Value Disclosure [Abstract] Level 1 Fair Value, Inputs, Level 1 [Member] Other-than-temporary declines in fair value of available-for-sale debt securities Other than Temporary Impairment Losses, Investments Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Entity Small Business Entity Small Business Operating Leases Lessee, Operating Lease, Liability, Payment, Due [Abstract] Cash equivalents: Cash and cash equivalents Cash and Cash Equivalents [Member] Base Rate Base Rate [Member] Increases related to current period tax positions Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions Commitments and Contingencies Commitments Disclosure [Text Block] Stock-based compensation expense: Share-based Compensation Allocation [Abstract] -- None. No documentation exists for this element. -- Liabilities and Shareholders’ Equity Liabilities and Equity [Abstract] Net unrecognized tax benefits which would affect the tax rate if recognized Unrecognized Tax Benefits that Would Impact Effective Tax Rate Accounts payable Increase (Decrease) in Accounts Payable Hedging Relationship [Domain] Hedging Relationship [Domain] Expected annual dividends Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Payments Derivative liability current, foreign currency forward contracts Derivative Liability, Current Entity Interactive Data Current Entity Interactive Data Current Additional Balance Sheet Detail Additional Financial Information Disclosure [Text Block] Settlement with tax authorities Unrecognized Tax Benefits, Decrease Resulting from Settlements with Taxing Authorities Marketable securities Marketable Securities, Current Change in fair value of contingent consideration (Decrease) increase in fair value of contingent consideration Decrease in fair value of contingent payments Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Balance Sheet Location [Domain] Balance Sheet Location [Domain] Balance at beginning of the period Balance at end of period Unrecognized tax benefits Unrecognized Tax Benefits Gross deferred tax assets Deferred Tax Assets, Gross Income Tax Authority [Domain] Income Tax Authority [Domain] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Gross Unrealized Gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Derivative asset current, foreign currency forward contracts Derivative Asset, Current Entity Address, State or Province Entity Address, State or Province Leases Lessee, Finance Leases [Text Block] Amounts reclassified from accumulated other comprehensive income (loss) Reclassification from AOCI, Current Period, Net of Tax, Attributable to Parent Collaborative arrangement development and regulatory potential milestone payments maximum Collaborative Arrangement Development And Regulatory Potential Milestone Payments Maximum Represents the potential milestone amount to be paid by the entity under the collaboration agreement if drug candidates are approved and commercialized. Deferred tax assets Deferred Income Tax Assets, Net United Kingdom UNITED KINGDOM Current liabilities: Liabilities, Current [Abstract] Beginning balance (in shares) Ending balance (in shares) Shares, Outstanding Weighted average exercise price exercisable at the end of the period ( in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Inventories Inventory Disclosure [Text Block] Corporate equity securities Equity Securities [Member] Percentage of employees eligible for acceleration of equity awards (less than) (percent) Percentage of employees eligible for acceleration of equity awards Percentage of employees eligible for acceleration of equity awards Accounting Policies [Abstract] Accounting Policies [Abstract] Number of optional renewal terms Lessee, Operating Lease, Number Of Renewal Options Lessee, Operating Lease, Number Of Renewal Options Outstanding (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Derivative Instrument [Axis] Derivative Instrument [Axis] Marketable Securities and Equity Investments Cash, Cash Equivalents, and Marketable Securities [Text Block] Federal Current Federal Tax Expense (Benefit) Present value of lease liabilities Operating Lease, Liability Schedule of PSU Activity Share-based Payment Arrangement, Performance Shares, Outstanding Activity [Table Text Block] Document Transition Report Document Transition Report Financial performance shares Financial Performance Shares [Member] Financial Performance Shares Common stock, $0.01 par value; 500,000,000 shares authorized, 254,479,046 and 259,889,549 shares issued and outstanding, respectively Common Stock, Value, Issued Finance leases Finance Lease, Weighted Average Discount Rate, Percent Weighted-average Recognition Period Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Beginning of the period ( in usd per share) End of the period ( in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Right to license, number of development programs Collaborative Arrangement, Right To License, Number Of Development Programs Collaborative Arrangement, Right To License, Number Of Development Programs Investment in equity securities and notes receivable Payment to Acquire Preferred Stock and Notes Receivable Payment to Acquire Preferred Stock and Notes Receivable Leases Lessee, Operating Leases [Text Block] Amortization of leased assets Finance Lease, Right-of-Use Asset, Amortization Reclassification out of Accumulated Other Comprehensive Income [Axis] Reclassification out of Accumulated Other Comprehensive Income [Axis] ICFR Auditor Attestation Flag ICFR Auditor Attestation Flag Schedule of Assumptions Used to Estimate the Grant Date Fair Value of Options Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Product Concentration Risk Product Concentration Risk [Member] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Foreign Deferred Foreign Income Tax Expense (Benefit) Legal Entity [Axis] Legal Entity [Axis] Share-based payment arrangements (in shares) Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements Marketable Securities Marketable Securities, Policy [Policy Text Block] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Interest expense Interest Income (Expense), Net British pound sterling United Kingdom, Pounds Summary of Unrecognized Tax Benefits Summary of Income Tax Contingencies [Table Text Block] Income Tax Authority [Axis] Income Tax Authority [Axis] Work-in-process Inventory, Work in Process, Net of Reserves Fair value of cash flow hedges Cash Flow Hedge Derivative Instrument Liabilities at Fair Value Computers and software Technology Equipment [Member] Thereafter Finance Lease, Liability, to be Paid, after Year Five Prepaid expenses and other current assets Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Stock options outstanding and exercisable Share-based Payment Arrangement, Option, Exercise Price Range [Line Items] Selling, general and administrative expenses Selling, General and Administrative Expenses [Member] Entity [Domain] Entity [Domain] Accrued expenses Total Accrued Liabilities, Current Revenue Product revenues, net Total product revenues, net Revenue from Contract with Customer, Excluding Assessed Tax Stock-based compensation Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost Finished goods Inventory, Finished Goods, Net of Reserves Long-term intercompany receivable write-off Effective Income Tax Rate Reconciliation, Intercompany Receivable Write-Off, Percent Effective Income Tax Rate Reconciliation, Intercompany Receivable Write-Off, Percent Stock options Stock options Share-based Payment Arrangement, Option [Member] Equity [Abstract] Equity [Abstract] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Comprehensive Income Comprehensive Income, Policy [Policy Text Block] Tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Percent Less: tenant allowance Finance Lease and Operating Lease, Liability, Tenant Allowance Finance Lease and Operating Lease, Liability, Tenant Allowance Operating lease assets Deferred Tax Assets, Operating Lease Assets Deferred Tax Assets, Operating Lease Assets Measurement Input Type [Domain] Measurement Input Type [Domain] Variable Rate [Axis] Variable Rate [Axis] Segment Information Segment Reporting Disclosure [Text Block] Uncertain tax positions Effective Income Tax Rate Reconciliation, Uncertian Tax Positions, Percent Effective Income Tax Rate Reconciliation, Uncertian Tax Positions, Percent Finance leases Finance Lease, Weighted Average Remaining Lease Term Other comprehensive income (loss) before reclassifications OCI, before Reclassifications, Net of Tax, Attributable to Parent Canadian dollar Canada, Dollars Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Weighted-average discount rate Weighted Average Discount Rate [Abstract] Weighted Average Discount Rate [Abstract] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-sale [Line Items] Matures after one year through five years Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, after Year One Through Five Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Document Fiscal Year Focus Document Fiscal Year Focus Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Variable Rate [Domain] Variable Rate [Domain] Additional Paid-in Capital Additional Paid-in Capital [Member] Intangible assets Deferred Tax Assets Intangibles The component of income tax expense for the period representing the increase (decrease) in the entity's deferred tax assets related to intangible assets. $200.01–$286.27 Exercise Price Range From Dollars 200.01 to Dollars $286.27 [Member] Exercise Price Range From Dollars 200.01 to Dollars $286.27 Other assets Other Assets [Member] Other income, net Other Nonoperating Income (Expense) Other liabilities Increase (Decrease) in Other Operating Liabilities Remaining milestone payment Business Combination, Remaining Milestone Payment Business Combination, Remaining Milestone Payment Maximum Maximum [Member] Share-based Payment Arrangement [Abstract] Share-based Payment Arrangement [Abstract] Gross Unrealized Losses Equity Securities, FV-NI, Unrealized Loss Schedule of Collaborative Arrangement on Research and Development Collaborative Arrangement and Arrangement Other than Collaborative [Table Text Block] Raw materials Inventory, Raw Materials, Net of Reserves Summary of Accrued Expenses Schedule of Accrued Liabilities [Table Text Block] Award Type [Axis] Award Type [Axis] Schedule of Operating Lease, Liability, Maturity Lessee, Operating Lease, Liability, Maturity [Table Text Block] Skyhawk Therapeutics Inc Skyhawk Therapeutics Inc [Member] Skyhawk Therapeutics Inc Beginning balance Ending balance Stockholders' Equity Attributable to Parent Fair Value of In-process Research and Development Assets and Contingent Payments In-process Research and Development Assets and Contingent Payments [Policy Text Block] Disclosure of accounting policy for costs assigned to identifiable tangible and intangible assets and contingent payments of an acquired entity to be used in the research and development activities of the combined enterprise. Common stock, number of votes per share Common Stock, Votes Per Each Share Common Stock, Votes Per Each Share City Area Code City Area Code Exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Designated as hedging instruments Designated as Hedging Instrument [Member] Goodwill and Intangible Assets Disclosure [Abstract] Goodwill and Intangible Assets Disclosure [Abstract] Repurchases of common stock Payments for Repurchase of Common Stock Number of leases Lease Agreement, Number of Leases Represents the number of leases entered by the reporting entity. Property and equipment useful life Property, Plant and Equipment, Useful Life AOCI, Net of Tax [Roll Forward] AOCI Including Portion Attributable to Noncontrolling Interest, Net of Tax [Roll Forward] Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Award Type [Axis] Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Award Type [Axis] This element represents the grouping of share-based compensation award types. Equity, Class of Treasury Stock [Line Items] Equity, Class of Treasury Stock [Line Items] Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Long-term operating lease liabilities Operating Lease, Liability, Noncurrent Total lease payments Finance Lease, Liability, Payment, Due Adjustments for New Accounting Pronouncements [Axis] Accounting Standards Update [Axis] Total current taxes Current Income Tax Expense (Benefit) Income tax effect Share-based Payment Arrangement, Expense, Tax Benefit Market share price ( in usd per share) Share Price Research and Development Expenses Research, Development, and Computer Software, Policy [Policy Text Block] Lease agreement initial term Lessee, Operating Lease, Term of Contract Restricted stock units (including PSUs) Restricted Stock Units (excluding PSUs) Restricted Stock Units (RSUs) [Member] Present value of lease liabilities Finance Lease, Liability Number of purchase periods Share-based Compensation Arrangement by Share-based Payment Award, Number of Purchase Periods Share-based Compensation Arrangement by Share-based Payment Award, Number of Purchase Periods Total deferred tax liabilities Deferred Tax Liabilities, Gross Operating Loss and Tax Credit, Carryforwards [Table] Operating Loss and Tax Credit, Carryforwards [Table] Schedule reflecting pertinent information, such as tax authority, amounts, and expiration dates, of net operating loss carryforwards, including an assessment of the likelihood of utilization and tax credit carryforwards. Tranche two Share-based Payment Arrangement, Tranche Two [Member] Share Repurchase Program [Axis] Share Repurchase Program [Axis] Contingent liabilities Contingent Liabilities Amount of material contingent liabilities outstanding Income Statement [Abstract] Income Statement [Abstract] Entity Registrant Name Entity Registrant Name 2024 Finance Lease, Liability, to be Paid, Year Three 2025 Finance Lease, Liability, to be Paid, Year Four Options outstanding, weighted-average exercise price ( in usd per share) Share-based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price Collaborative Arrangement Agreement [Domain] Collaborative Arrangement Agreement [Domain] Listing of significant collaboration agreements. Forfeited ( in usd per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Provision for income taxes Provision for income taxes Income Tax Expense (Benefit) Accounts receivable, net Accounts Receivable, after Allowance for Credit Loss, Current Accumulated Other Comprehensive Income (Loss) [Table] Accumulated Other Comprehensive Income (Loss) [Table] Summary of Cash, Cash Equivalents and Marketable Securities Cash, Cash Equivalents and Investments [Table Text Block] Entity Tax Identification Number Entity Tax Identification Number Document Fiscal Period Focus Document Fiscal Period Focus Total current assets Assets, Current Schedule of Stock Options Outstanding and Exercisable Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block] Percent of Accounts Receivable Accounts Receivable [Member] Total lease payments Lessee, Operating Lease, Liability, to be Paid Cancelled (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period In-process Research and Development Assets Goodwill and Intangible Assets Indefinite-Lived Assets [Policy Text Block] Describes an entity's accounting policy for indefinite-lived intangible assets (that is, those intangible assets not subject to amortization). This accounting policy also may address how the entity assesses whether events and circumstances continue to support an indefinite useful life and how the entity assesses and measures impairment of such assets. Repurchases of common stock Repurchases of common stock Stock Repurchased During Period, Value Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Indemnification claims Indemnification Claims Amount of indemnification claims currently outstanding Length of lease Lessee Leasing Arrangements, Capital Leases, Term of Contract Lessee Leasing Arrangements, Capital Leases, Term of Contract Property, Plant and Equipment, Type [Domain] Long-Lived Tangible Asset [Domain] Long-Lived Tangible Asset [Domain] Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Derivative Instruments, Gain (Loss) [Line Items] Derivative Instruments, Gain (Loss) [Line Items] Stock compensation (benefit), shortfalls and cancellations Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Payment Arrangement, Percent Debt covenant, increase in consolidated leverage ratio Debt Covenant, Increase In Consolidated Leverage Ratio Debt Covenant, Increase In Consolidated Leverage Ratio Other indefinite-lived intangible assets Other Indefinite-lived Intangible Assets Schedule of Cash Equivalents and Available-for-sale Securities [Table] Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Table] Schedule of the cash and cash equivalents and available-for-sale investments held by the entity. Percent of Total Gross Product Revenues Revenue Benchmark [Member] Weighted-average grant-date fair value, granted ( in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Equity Component [Domain] Equity Component [Domain] 2022 Lessee, Operating Lease, Liability, to be Paid, Year One Less: amount representing interest Finance Lease And Operating Lease, Liability, Undiscounted Excess Amount Finance Lease And Operating Lease, Liability, Undiscounted Excess Amount Deferred tax assets: Components of Deferred Tax Assets [Abstract] Property and equipment, net Total property and equipment, net Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, after Accumulated Depreciation and Amortization Share Repurchase Programs Stockholders' Equity, Policy [Policy Text Block] Employee stock purchase program (in shares) Incremental Common Shares Attributable to Dilutive Effect of Equity Unit Purchase Agreements Counterparty Name [Domain] Counterparty Name [Domain] 2025 Lessee, Operating Lease, Liability, to be Paid, Year Four Weighted Average Weighted Average [Member] Finance lease liabilities Finance Lease, Liability, Current Issuance of common stock under benefit plans (in shares) Stock Issued During Period, Shares, Employee Benefit Plan Income before provision for income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Level 2 Fair Value, Inputs, Level 2 [Member] Type of Adoption [Domain] Accounting Standards Update [Domain] Deferred tax benefit Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount Auditor Location Auditor Location Segment Reporting [Abstract] Segment Reporting [Abstract] Option to extend lease term Lessee, Finance Lease, Term of Contract Amortized Cost Debt Securities, Available-for-sale, Amortized Cost Revenue from External Customers by Products and Services [Table] Revenue from External Customers by Products and Services [Table] Interest on lease liabilities Finance Lease, Interest Expense Use of Estimates Use of Estimates, Policy [Policy Text Block] Schedule of Earnings Per Share, Basic and Diluted Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Financial instruments carried at fair value (liability position): Financial Liabilities Fair Value Disclosure [Abstract] Total other comprehensive income (loss) Other comprehensive income (loss), net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Finance Leases Finance Lease, Liability, Payment, Due [Abstract] Title of 12(b) Security Title of 12(b) Security Moderna Agreement Moderna Agreement [Member] Moderna Agreement [Member] Common stock, shares authorized (in shares) Common Stock, Shares Authorized Average price paid per share ( in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Per Share Weighted Average Price of Shares Purchased Document Type Document Type Product and Service [Domain] Product and Service [Domain] Product revenue accruals Product Sales Accrued Liabilities Total of product sales allowances and reserves that reflect a liability established to represent expected future costs. Legal Offset Derivative Asset, Fair Value, Offset Against Collateral, Net of Not Subject to Master Netting Arrangement, Policy Election Optional term of lease agreement (in years) Lessee, Operating Lease, Renewal Term Balance at December 31, 2020 Balance at December 31, 2021 Business Combination, Contingent Consideration, Liability Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Weighted-average cost basis Amortized Cost Equity Securities, FV-NI, Cost Revolving Credit Facility Revolving Credit Facility [Member] Fair Value by Measurement Frequency [Axis] Measurement Frequency [Axis] Summary of cash, cash equivalents and marketable securities Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Line Items] -- None. No documentation exists for this element. -- Share-based Payment Arrangement, Option, Exercise Price Range [Table] Share-based Payment Arrangement, Option, Exercise Price Range [Table] Schedule of Lease Cost Lease, Cost [Table Text Block] Geographical [Axis] Geographical [Axis] Commercial paper Commercial Paper, Not Included with Cash and Cash Equivalents [Member] State and Local Jurisdiction State and Local Jurisdiction [Member] Corporate Headquarters Fan Pier Leases [Member] Represents the fan pier leases. Vesting [Domain] Vesting [Domain] Product revenues, net Product revenues, net Product [Member] Total financial liabilities Financial Liabilities Fair Value Disclosure Hedging Relationship [Axis] Hedging Relationship [Axis] Share Repurchase Program 2020 Share Repurchase Program 2020 [Member] Share Repurchase Program 2020 [Member] Net unrealized gains Unrealized Gain (Loss) on Investments Net cash (used in) provided by financing activities Net Cash Provided by (Used in) Financing Activities Shares used in per share calculations: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Vesting period Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Schedule of Restricted Stock and Restricted Stock Units Activity Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] Schedule of Finance Lease, Liability, Maturity Finance Lease, Liability, Fiscal Year Maturity [Table Text Block] Fair Value Measurements Fair Value Disclosures [Text Block] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Other current liabilities Finance Leases, Other Current Liabilities Finance Leases, Other Current Liabilities Derivative Instruments and Hedging Activities Disclosures [Table] Derivative Instruments and Hedging Activities Disclosures [Table] Share Repurchase Program 2021 Share Repurchase Program 2021 [Member] Share Repurchase Program 2021 Optional renewal term length Lessee Leasing Arrangements, Capital Leases, Renewal Term Lessee Leasing Arrangements, Capital Leases, Renewal Term Foreign Tax Authority Foreign Tax Authority [Member] Royalty payable Accrued Royalties, Current Gross Unrealized Gains Debt and Equity Securities, Unrealized Gain Debt and Equity Securities, Unrealized Gain Derivative [Table] Derivative [Table] Goodwill Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block] 2024 Finance Lease And Operating Lease, Liability, Payment, Due Year Three Finance Lease And Operating Lease, Liability, Payment, Due Year Three Computers and software Computer Software, Intangible Asset [Member] Document Period End Date Document Period End Date Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Marketable securities: Marketable securities Marketable Securities [Member] Marketable Securities [Member] Stock Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Exonics Therapeutics Exonics Therapeutics [Member] Exonics Therapeutics [Member] Arbor Biotechnologies, Inc Arbor Biotechnologies, Inc [Member] Arbor Biotechnologies, Inc Sale of equity securities Proceeds from Sale of Debt and Equity Securities, FV-NI, Held-for-investment State taxes, net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent State Deferred State and Local Income Tax Expense (Benefit) Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Schedule of Property and Equipment Property, Plant and Equipment [Table Text Block] Finance lease liabilities Deferred Tax Assets, Lease Obligation Deferred Tax Assets, Lease Obligation Income Statement Location [Domain] Income Statement Location [Domain] Less: tenant allowance Lessee, Operating Lease, Liability, Tenant Allowance Lessee, Operating Lease, Liability, Tenant Allowance Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] Additional shares authorized (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized Semma Therapeutics, Inc. Semma Therapeutics, Inc. [Member] Semma Therapeutics, Inc. [Member] Marketable securities: Marketable Securities Net income per common share: Earnings Per Share [Abstract] Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Gains on equity securities Equity Securities, FV-NI, Unrealized Gain (Loss) Contract liabilities Other Contract Liabilities Current Other Contract liabilities, Current Outstanding at beginning of period ( in usd per share) Outstanding at end of period ( in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Costs and expenses: Costs and Expenses [Abstract] Percent of awards in tranche Share-Based Compensation By Share-Based Payment Award, Percent of Awards in Tranche Share-Based Compensation By Share-Based Payment Award, Percent of Awards in Tranche Europe Europe [Member] Entity Current Reporting Status Entity Current Reporting Status Effective tax rate Effective tax rate Effective Income Tax Rate Reconciliation, Percent Proceeds received Proceeds from Sale and Maturity of Marketable Securities Counterparty Name [Axis] Counterparty Name [Axis] United States UNITED STATES Discount Rate Measurement Input, Discount Rate [Member] Significant Customers Schedules of Concentration of Risk, by Risk Factor [Table Text Block] Tax related accruals Taxes Payable, Current Leases [Abstract] Leases [Abstract] Income Taxes Income Tax, Policy [Policy Text Block] Accumulated Other Comprehensive Income (Loss) [Line Items] Accumulated Other Comprehensive Income (Loss) [Line Items] Entity Address, Postal Zip Code Entity Address, Postal Zip Code Revenue Recognition Revenue from Contract with Customer [Policy Text Block] Diluted (in shares) Diluted weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Diluted United States Income (Loss) from Continuing Operations before Income Taxes, Domestic Income Taxes Income Tax Disclosure [Text Block] Schedule of Outstanding and Vested Options Share-based Payment Arrangement, Option, Activity [Table Text Block] Basis spread on variable rate (percent) Debt Instrument, Basis Spread on Variable Rate Fair Value Debt and Equity Securities, Fair Value Debt and Equity Securities, Fair Value Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Name of Property [Axis] Name of Property [Axis] Credit Facility [Axis] Credit Facility [Axis] Indefinite-Lived Intangible Assets [Line Items] Indefinite-lived Intangible Assets [Line Items] Not designated as hedging instrument Not Designated as Hedging Instrument [Member] Entity Address, Address Line One Entity Address, Address Line One Total lease payments Finance Lease And Operating Lease, Liability, Payments, Due Finance Lease And Operating Lease, Liability, Payments, Due Collaborative Arrangement, Transaction with Party to Collaborative Arrangement Collaborative Arrangement, Transaction with Party to Collaborative Arrangement [Member] Unrealized holding (losses) gains on marketable securities, net Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Schedule of Prepaid, and Other Assets Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block] Entity Shell Company Entity Shell Company Total Finance Leas and Operating Lease, Liabilities, Payments, Due [Abstract] Finance Leas and Operating Lease, Liabilities, Payments, Due [Abstract] Derivative Instruments and Hedging Activities Disclosures [Line Items] Derivative Instruments and Hedging Activities Disclosures [Line Items] Expected term of options (in years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Total current liabilities Liabilities, Current Employee stock purchase plan Employee Stock [Member] Payments in connection with common stock withheld for employee tax obligations Payment, Tax Withholding, Share-based Payment Arrangement Foreign currency forward contracts Foreign Exchange Forward [Member] Money market funds Money Market Funds [Member] Reclassification out of Accumulated Other Comprehensive Income Reclassification out of Accumulated Other Comprehensive Income [Member] Current Fiscal Year End Date Current Fiscal Year End Date Derivative Instruments, Gain (Loss) [Table] Derivative Instruments, Gain (Loss) [Table] Statement [Table] Statement [Table] Line of credit facility, additional borrowing capacity Line Of Credit Facility Additional Borrowing Capacity Amount of increased borrowing capacity available in the future. Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Recently Adopted Accounting Standards and Recently Issued Accounting Standards New Accounting Pronouncements, Policy [Policy Text Block] Other Deferred Tax Assets, Other Weighted-average assumptions for options and ESPP subscriptions granted Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract] Unrecognized Expense Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Statistical Measurement [Axis] Statistical Measurement [Axis] Accounts Receivable Accounts Receivable [Policy Text Block] Long-term finance lease liabilities Finance Lease, Liability, Noncurrent Goodwill Goodwill Total assets Offsetting Derivative Assets [Abstract] Foreign income tax rate differential Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent Schedule of Unrecognized Stock-Based Compensation Expense Schedule of Unrecognized Share-based Compensation Expense [Table Text Block] Disclosure as of the latest balance-sheet date presented of the total compensation cost related to outstanding, nonvested share-based compensation awards not yet recognized, net of estimated forfeitures, and the weighted average period over which those unrecognized costs are expected to be reported. 2006 Stock and Option Plan Stock and Option Plan 2006 [Member] The element describes the details pertaining to the 2006 Stock and Option Plan. Operating lease cost Operating Lease, Cost Maximum percentage of annual compensation contributed by the participant (percent) Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent Total deferred taxes Deferred Income Tax Expense (Benefit) Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Number of shares authorized to be repurchased Stock Repurchase Program, Authorized Amount Hedging Designation [Domain] Hedging Designation [Domain] Federal statutory tax rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Net Income Per Common Share Earnings Per Share, Policy [Policy Text Block] Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value Hierarchy and NAV [Domain] Net income Net income Net income Net Income (Loss) Attributable to Parent Operating lease assets Total operating lease assets Operating Lease, Right-of-Use Asset Schedule of Cash Flow Hedging Instruments Schedule of Notional Amounts of Outstanding Derivative Positions [Table Text Block] Net operating loss Deferred Tax Assets, Operating Loss Carryforwards Debt covenant, consolidated leverage ratio Debt Covenant, Consolidated Leverage Ratio Consolidated leverage ratio that must be maintained in order to be in compliance with debt covenants. Payroll and benefits Employee-related Liabilities, Current Income Statement Location [Axis] Income Statement Location [Axis] Statistical Measurement [Domain] Statistical Measurement [Domain] Schedule of Offsetting Assets Offsetting Assets [Table Text Block] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Revenues: Revenue from Contract with Customer [Abstract] Additional paid-in capital Additional Paid in Capital, Common Stock Other assets Other Assets, Noncurrent Entity File Number Entity File Number Stock-based compensation expense APIC, Share-based Payment Arrangement, Increase for Cost Recognition Deferred Tax Assets Deferred Tax Assets [Member] Deferred Tax Assets [Member] Credit Concentration Risk Credit Concentration Risk [Member] Less: tenant allowance Finance Lease, Liability ,Tenant Allowance Finance Lease, Liability ,Tenant Allowance Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Variable lease cost Variable Lease, Cost Buildings and improvements Building [Member] Restricted stock vested in period, total fair value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value Granted ( in usd per share) Granted (in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Total property and equipment, gross Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, before Accumulated Depreciation and Amortization Maturities of available-for-sale debt securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale Restricted Cash and Cash Equivalents Items [Line Items] Restricted Cash and Cash Equivalents Items [Line Items] Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Axis] Exercise Price Range [Axis] Share Repurchase Program [Domain] Share Repurchase Program [Domain] Stock Options Equity Option [Member] Credit Facility [Domain] Credit Facility [Domain] Schedule of Fair Value of Our Contingent Consideration Liabilities Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table Text Block] Assets Assets [Abstract] Land Land [Member] Finance leases Right-of-Use Asset Obtained in Exchange for Finance Lease Liability Schedule of Components of Lease in Balance Sheets Assets And Liabilities, Lessee [Table Text Block] Assets And Liabilities, Lessee [Table Text Block] Other revenues Collaborative and Royalty [Member] Collaborative and Royalty [Member] Hedging Derivative Instruments and Hedging Activities Disclosure [Text Block] Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Restrictions on Cash and Cash Equivalents [Table] Restrictions on Cash and Cash Equivalents [Table] Concentration risk percentage Concentration Risk, Percentage Intangible Assets and Goodwill Goodwill and Intangible Assets Disclosure [Text Block] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Issuances of common stock under benefit plans Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised New Accounting Pronouncements or Change in Accounting Principle [Table] Accounting Standards Update and Change in Accounting Principle [Table] Outstanding at beginning of period (in shares) Outstanding at end of period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Total marketable debt securities Debt Securities, Available-for-sale [Abstract] Share Repurchase Program 2018 Share Repurchase Program 2018 [Member] Share Repurchase Program 2018 [Member] Other Other Sundry Liabilities, Current Gross Amounts Not Offset Derivative Liability, Not Offset, Policy Election Deduction Contingent consideration, measurement input (percent) Business Combination, Contingent Consideration, Liability, Measurement Input Operating leases Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Schedule of Deferred Tax Assets and Liabilities Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Vesting percentage Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Stock-based compensation expense related to inventories Share-based Payment Arrangement, Amount Capitalized CRSIPR A&R JDCA CRSIPR A&R JDCA [Member] CRISPR Amended and restated the Original CTX001 JDCA Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] Other Other Countries Outside of the United States and the United Kingdom [Member] Other Countries Outside of the United States and the United Kingdom [Member] Amount of optional renewal terms Amount of Optional Renewal Terms Amount of Optional Renewal Terms Number of operating segments Number of Operating Segments McKesson Corporation McKesson Corporation [Member] McKesson Corporation [Member] 2024 Lessee, Operating Lease, Liability, to be Paid, Year Three Defined contribution plan, cost Defined Contribution Plan, Cost Number of Shares Number of Units Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Tax credit carryforwards Deferred Tax Assets, Tax Credit Carryforwards Interest income Investment Income, Interest and Dividend Common stock withheld for employee tax obligations Share-based Payment Arrangement, Decrease for Tax Withholding Obligation Number of shares authorized (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Operating cash flows from operating leases Operating Lease, Payments Australian dollar Australia, Dollars Common Stock, Preferred Stock and Equity Plans Common Stock, Preferred Stock and Equity Plans Disclosure [Text Block] Disclosures related to shares available for future issuance, descriptions of the stock and option plans, and the rights associated with each share. Right-of-use assets obtained in exchange for lease obligations Right-Of-Use Asset Obtained In Exchange For Lease Liability [Abstract] Right-Of-Use Asset Obtained In Exchange For Lease Liability [Abstract] Total finance lease assets Finance Lease, Right-of-Use Asset, after Accumulated Amortization Total financial assets Assets, Fair Value Disclosure Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward] Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward] Investment in collaborative partner, pursuant to convertible loan agreement Collaborative Arrangement, Investment in Collaborative Partner, Amount Collaborative Arrangement, Investment in Collaborative Partner, Amount Total liabilities and shareholders’ equity Liabilities and Equity Other Effective Income Tax Rate Reconciliation, Other Adjustments, Percent Other Other Accrued Liabilities, Current Investments, Debt and Equity Securities [Abstract] Investments, Debt and Equity Securities [Abstract] Deferred tax benefit Effective Income Tax Rate Reconciliation, Inter-Entity Transfer Of Intellectual Property Rights, Amount Effective Income Tax Rate Reconciliation, Inter-Entity Transfer Of Intellectual Property Rights, Amount Tranche one Share-based Payment Arrangement, Tranche One [Member] Publicly Traded Companies Sale Publicly Traded Companies Sale [Member] Publicly Traded Companies Sale [Member] Lloyds Pharmacy Lloyds Pharmacy [Member] Lloyds Pharmacy 2026 Lessee, Operating Lease, Liability, to be Paid, Year Five Exercised ( in usd per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Weighted-average 
Grant-date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Additional Disclosures [Abstract] Legal Offset Derivative Liability, Fair Value, Offset Against Collateral, Net of Not Subject to Master Netting Arrangement, Policy Election Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Audit Information [Abstract] Audit Information [Abstract] Concentration Risk [Line Items] Concentration Risk [Line Items] Derivative [Line Items] Derivative [Line Items] Options exercisable, weighted-average exercise price ( in usd per share) Share-based Payment Arrangement, Option, Exercise Price Range, Exercisable, Weighted Average Exercise Price Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Research, development and commercial contract costs Accrued Research Development and Commercial Contract Costs This element represents the carrying value as of the balance sheet date of obligations incurred through that date and payable for R&D and commercial of the entity. It is used to reflect the current portion of liabilities (due within one year or within the normal operating cycle, if longer). Earnings Per Share Earnings Per Share [Text Block] KALYDECO KALYDECO [Member] KALYDECO inventories, net Molecular Templates, Inc Molecular Templates, Inc [Member] Molecular Templates, Inc Minimum Minimum [Member] Potential awards, percent of target shares, minimum Share-Based Compensation By Share-Based Payment Award, Award Percentage Of Target, Minimum Share-Based Compensation By Share-Based Payment Award, Award Percentage Of Target, Minimum Inter-entity transfer of intellectual property rights Effective Income Tax Rate Reconciliation, Inter-Entity Transfer Of Intellectual Property Rights, Percent Effective Income Tax Rate Reconciliation, Inter-Entity Transfer Of Intellectual Property Rights, Percent Duration of purchase period Share-based Compensation Arrangement by Share-based Payment Award, Duration of Purchase Period Share-based Compensation Arrangement by Share-based Payment Award, Duration of Purchase Period 2023 Lessee, Operating Lease, Liability, to be Paid, Year Two Effect of changes in exchange rates on cash Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Schedule of Revenues from External Customers and Long-Lived Assets [Table] Schedule of Revenues from External Customers and Long-Lived Assets [Table] ORKAMBI ORKAMBI [Member] ORKAMBI [Member] Selling, general and administrative expenses Selling, General and Administrative Expense Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Finance leases Finance Lease, Right-of-Use Asset, after Accumulated Amortization [Abstract] Cumulative Effect, Period of Adoption [Axis] Cumulative Effect, Period of Adoption [Axis] Payments to acquire businesses, net of cash acquired Payments to Acquire Businesses, Net of Cash Acquired Tax related prepaid and receivables Tax Related Prepaid and Receivables Tax Related Prepaid and Receivables Foreign Currency Translation Adjustment Foreign Currency Forward Contract Accumulated Foreign Currency Adjustment Attributable to Parent [Member] Schedule of Components of Provision for (Benefit From) Income Taxes Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Options exercisable (in shares) Share-based Payment Arrangement, Option, Exercise Price Range, Shares Exercisable Stock-based Compensation Expense Share-based Payment Arrangement [Text Block] Cash paid for amounts included in the measurement of lease liabilities Cash Flow, Lessee [Abstract] Cash Flow, Lessee [Abstract] Level 3 Fair Value, Inputs, Level 3 [Member] Leases Lessee, Leases [Policy Text Block] Less: accumulated depreciation Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, Accumulated Depreciation and Amortization Up-front payment Collaborative Arrangement Up-front License Fee The amount of the up-front license fee paid by the entity pursuant to a collaborative arrangement. 2023 Finance Lease And Operating Lease, Liability, Payment, Due Year Two Finance Lease And Operating Lease, Liability, Payment, Due Year Two Revenues by Product Revenue from External Customers by Products and Services [Table Text Block] Net foreign currency transaction loss Foreign Currency Transaction Gain (Loss), before Tax Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Performance-based RSUs Performance Shares [Member] Commitments and contingencies Commitments and Contingencies 2013 Stock and Option Plan Stock and Option Plan 2013 [Member] Stock and Option Plan 2013 [Member] Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax Entity Emerging Growth Company Entity Emerging Growth Company Class of Treasury Stock [Table] Class of Treasury Stock [Table] Restricted Stock Restricted stock units (including PSUs) Restricted Stock [Member] Auditor Name Auditor Name Cover [Abstract] Cover [Abstract] Gross Unrealized Gains Equity Securities, FV-NI, Unrealized Gain Revenues from External Customers and Long-Lived Assets [Line Items] Revenues from External Customers and Long-Lived Assets [Line Items] Total costs and expenses Costs and Expenses Finance Lease, Liability, Current, Statement of Financial Position [Extensible List] Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] Amortized Cost Debt and Equity Securities, Cost Debt and Equity Securities, Cost Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Summary of Other Current Liabilities Other Current Liabilities [Table Text Block] Collaborative Arrangements by Agreement [Axis] Collaborative Arrangements by Agreement [Axis] Significant terms of collaboration arrangements, by individual agreement. Less: amount representing interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Share Repurchase Program 2019 Share Repurchase Program 2019 [Member] Share Repurchase Program [Member] Cash Cash Schedule of Additional Cash Flow Information Condensed Cash Flow Statement [Table Text Block] Financial Instrument [Axis] Financial Instrument [Axis] Unrecognized Tax Benefits [Table] Unrecognized Tax Benefits [Table] Unrecognized Tax Benefits Options outstanding, weighted-average remaining contractual life Share-based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Remaining Contractual Term Less: amount representing interest Finance Lease, Liability, Undiscounted Excess Amount Current taxes: Current Income Tax Expense (Benefit), Continuing Operations [Abstract] San Diego Lease San Diego Lease [Member] San Diego Lease [Member] 2026 Finance Lease, Liability, to be Paid, Year Five Common Stock Common Stock [Member] Foreign Income (Loss) from Continuing Operations before Income Taxes, Foreign Income from operations Operating Income (Loss) Total liabilities Offsetting Derivative Liabilities [Abstract] Other current liabilities Operating Lease, Liability, Current Gross Unrealized Losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Nature of Business and Accounting Policies Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Collaborative and Other Arrangements Collaborative Arrangement Disclosure [Text Block] Hedging Designation [Axis] Hedging Designation [Axis] Stock-based compensation expense Share-based Payment Arrangement, Noncash Expense Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Depreciation expense Depreciation Purchases of available-for-sale debt securities Payments to Acquire Debt Securities, Available-for-sale Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Operating Lease, Liability, Current, Statement of Financial Position [Extensible List] Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] Notional amount of foreign currency forward contract Derivative, Notional Amount Deferred tax benefit Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount Schedule of Stock and Stock Equity Plans Schedule of Stock and Stock Option, Equity Plans [Table Text Block] This schedule discloses the information pertaining to stock and stock option plans relating to the entity's equity. Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Other current liabilities Total Other Liabilities, Current 2022 Finance Lease And Operating Lease, Liability, Payment, Due Next Twelve Months Finance Lease And Operating Lease, Liability, Payment, Due Next Twelve Months Total liabilities Liabilities Collaborative arrangement, milestone payment Collaborative Arrangement, Milestone Payment Collaborative Arrangement, Milestone Payment Merck KGaA Merck KGaA [Member] Merck KGaA Granted ( in usd per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Stock-based compensation expense Share-based Payment Arrangement, Expensed and Capitalized, Amount Expired (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period Corporate equity securities Equity Securities, FV-NI and without Readily Determinable Fair Value [Abstract] Measurement Input Type [Axis] Measurement Input Type [Axis] Mammoth Biosciences, Inc Mammoth Biosciences, Inc [Member] Mammoth Biosciences, Inc Operating loss carryforwards Operating Loss Carryforwards Common stock, shares issued (in shares) Common Stock, Shares, Issued Schedule of Sale of Equity Investments Debt Securities, Trading, and Equity Securities, FV-NI [Table Text Block] Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Entity Address, City or Town Entity Address, City or Town Variable Interest Entities Consolidation, Variable Interest Entity, Policy [Policy Text Block] Eurodollar Eurodollar [Member] Schedule of Accumulated Other Comprehensive Income (Loss) Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Schedule of Indefinite-Lived Intangible Assets by Major Class [Table] Schedule of Indefinite-Lived Intangible Assets [Table] Unrealized gains (losses) on foreign currency forward contracts, net of tax of $(21.8), $14.3 and $7.0, respectively Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), after Reclassification and Tax, Parent Balance Sheet Location [Axis] Balance Sheet Location [Axis] Accumulated Other Comprehensive Income (Loss) Comprehensive Income (Loss) Note [Text Block] Derivative asset noncurrent, foreign currency forward contracts Derivative Asset, Noncurrent Deferred income taxes Increase (Decrease) in Other Deferred Liability Awards outstanding (in shares) Share-Based Compensation Arrangement By Share-based Payment Award, Equity Instruments Outstanding, Number Share-Based Compensation Arrangement By Share-based Payment Award, Equity Instruments Outstanding, Number Measurement Frequency [Domain] Measurement Frequency [Domain] Accounting Standards Update 2016-02 Accounting Standards Update 2016-02 [Member] 2022 Finance Lease, Liability, to be Paid, Year One Deferred taxes: Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract] 2026 Finance Lease And Operating Lease, Liability, Payments, Due Year Five Finance Lease And Operating Lease, Liability, Payments, Due Year Five Retained earnings Accumulated deficit Retained Earnings (Accumulated Deficit) Expiration period Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Number of shares (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Entity Filer Category Entity Filer Category Schedule of Weighted-Average Remaining Lease Terms and Discount Rates Schedule of Weighted-Average Remaining Lease Terms and Discount Rates Related to Leases [Table Text Block] Schedule of Weighted-Average Remaining Lease Terms and Discount Rates Related to Leases [Table Text Block] Unrealized (losses) gains on foreign currency forward contracts, tax Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), after Reclassification, Tax, Parent Risk-free interest rate (percent) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate U.S. Treasury securities US Treasury Securities [Member] Concentration Risk [Table] Concentration Risk [Table] Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Schedule of Foreign Exchange Contracts Schedule of Foreign Exchange Contracts, Statement of Financial Position [Table Text Block] Weighted-average Remaining Contractual Life Weighted Average, Remaining Contractual Life [Abstract] -- None. No documentation exists for this element. -- Schedule of Shares Issued Under Employee Stock Purchase Plan Schedule of Share-based Compensation, Employee Stock Purchase Plan, Activity [Table Text Block] Total cash received from employees as a result of employee stock option exercises Proceeds from Stock Options Exercised 2023 Finance Lease, Liability, to be Paid, Year Two Schedule of Supplemental Cash Flow Information Lease, Supplemental Cash Flow Information [Table Text Block] Lease, Supplemental Cash Flow Information [Table Text Block] Derivative term Derivative, Term of Contract Total shareholders’ equity Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest Amendment Flag Amendment Flag Proceeds from finance leases Proceeds From Finance Leases Proceeds From Finance Leases Equity Components [Axis] Equity Components [Axis] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Concentration Risk Type [Domain] Concentration Risk Type [Domain] Inventories Total Inventory, Net Granted (in shares) Stock options granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures Federal Deferred Federal Income Tax Expense (Benefit) Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Expired ( in usd per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Thereafter Lessee, Operating Lease, Liability, to be Paid, after Year Five Long-term contingent consideration Long-term contingent consideration Business Combination, Contingent Consideration, Liability, Noncurrent Product and Service [Axis] Product and Service [Axis] Share-based Payment Arrangement, Additional Disclosure [Abstract] Share-based Payment Arrangement, Additional Disclosure [Abstract] Equity securities without readily determinable fair value, amount Equity Securities without Readily Determinable Fair Value, Amount Preferred stock, par value ( in usd per share) Preferred Stock, Par or Stated Value Per Share Entity Public Float Entity Public Float Documents Incorporated by Reference Documents Incorporated by Reference [Text Block] Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Award Type [Domain] Schedule of Share-based Compensation Arrangement by Share-based Payment Award, Award Type [Domain] This element represents an individual share-based compensation award type. Repurchases of common stock (in shares) Repurchases of common stock (in shares) Stock Repurchased During Period, Shares Accrued expenses Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Statement [Line Items] Statement [Line Items] Statement [Line Items] $150.01–$200.00 Exercise Price Range from Dollars 150.01 to Dollars 200.00 [Member] Represents the range of exercise prices from $150.01 to $200.00 per share for the purpose of disclosing shares potentially issuable under outstanding stock options, as well as other option information. Weighted-average remaining lease term (in years) Weighted-Average Remaining Lease [Abstract] Weighted-Average Remaining Lease [Abstract] Domestic Tax Authority Domestic Tax Authority [Member] $100.01–$150.00 Exercise Price Range from Dollars 100.01 to Dollars 150.00 [Member] Represents the range of exercise prices from $100.01 to $150.00 per share for the purpose of disclosing shares potentially issuable under outstanding stock options, as well as other option information. Fair Value Debt Securities Total Debt Securities, Available-for-sale Accrued expenses Accrued Liabilities, Current [Abstract] Schedule of Stock-Based Compensation Expense by Type of Award Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block] Property, Plant and Equipment, Type [Axis] Long-Lived Tangible Asset [Axis] Long-Lived Tangible Asset [Axis] Valuation allowance Valuation allowance Deferred Tax Assets, Valuation Allowance Customer [Axis] Customer [Axis] Document Annual Report Document Annual Report Schedule of Stock-Based Compensation Expense Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Vesting [Axis] Vesting [Axis] Total assets Assets Deferred tax liabilities: Components of Deferred Tax Liabilities [Abstract] Plan Name [Domain] Plan Name [Domain] Kymera Therapeutics Kymera Therapeutics [Member] Kymera Therapeutics [Member] Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Geographical [Domain] Geographical [Domain] CRISPR CRISPR [Member] CRISPR Research and development expenses Research and Development Expense Derivative Contract [Domain] Derivative Contract [Domain] $36.28–$100.00 Exercise Price Range from Dollars 36.28 to Dollars 100.00 [Member] Represents the range of exercise prices from $36.28 to $100.00 per share for the purpose of disclosing shares potentially issuable under outstanding stock options, as well as other option information. Accounts Payable and Accrued Liabilities Accounts Payable and Accrued Liabilities [Member] Cumulative Effect, Period of Adoption [Domain] Cumulative Effect, Period of Adoption [Domain] Present value of lease liabilities Finance Lease And Operating Lease, Liability Finance Lease And Operating Lease, Liability All Currencies [Domain] All Currencies [Domain] Net cash provided by operating activities Net Cash Provided by (Used in) Operating Activities Tax credit carryforwards Tax Credit Carryforward, Amount Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Furniture and equipment Furniture and equipment Furniture and Fixtures [Member] Basic (in shares) Basic weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Basic Diluted (in usd per share) Diluted net income per common share (in dollars per share) Earnings Per Share, Diluted U.S. tax on foreign earnings, net of credits Effective Income Tax Rate Reconciliation, Repatriation of Foreign Earnings, Percent Effect of potentially dilutive securities: Incremental Weighted Average Shares Attributable to Dilutive Effect [Abstract] Innovation Square Lease Innovation Square Lease [Member] Innovation Square Lease Cash paid for income taxes Income Taxes Paid, Net Swiss Franc Switzerland, Francs Accounting Standards Update [Extensible List] Accounting Standards Update [Extensible Enumeration] Finance lease cost Lease, Cost [Abstract] Intangible assets Intangible Assets, Net (Excluding Goodwill) Comprehensive income Comprehensive Income (Loss), Net of Tax, Attributable to Parent Contract liabilities Contract with Customer, Liability Other comprehensive income: Other Comprehensive Income (Loss), Net of Tax [Abstract] Other long-term liabilities Other Noncurrent Liabilities [Member] Derivative liability noncurrent, foreign currency forward contracts Derivative Liability, Noncurrent Right to license, number of clinical stage programs Collaborative Arrangement, Right to License, Number Of Clinical Stage Programs Collaborative Arrangement, Right To License, Number Of Clinical Stage Programs Corporate debt securities Corporate Debt Securities [Member] Accounts payable Accounts Payable, Current Gross Amounts Not Offset Derivative Asset, Not Offset, Policy Election Deduction Depreciation expense Depreciation, Depletion and Amortization Tax rate change Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent Schedule of Financial Assets Subject to Fair Value Measurements (Excluding Vie Cash and Cash Equivalents, Which are Recorded as Restricted Cash and Cash Equivalents (Vie)) Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Total stock-based compensation included in costs and expenses, net of tax Share-based Payment Arrangement, Expense, after Tax Tax Carryforwards [Line Items] Tax Carryforwards [Line Items] -- None. No documentation exists for this element. -- CRISPR Therapeutics CRISPR Therapeutics AG [Member] CRISPR Therapeutics AG Accumulated Other Comprehensive Income (Loss) Total AOCI Attributable to Parent [Member] Inventories Increase (Decrease) in Inventories Allocation of net profits and net losses, percent Collaborative Arrangement, Allocation Of Net Profits And Losses, Percent Collaborative Arrangement, Allocation Of Net Profits And Losses, Percent Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Schedule of Company’s Net Unrealized Gains on Corporate Equity Securities Unrealized Gain (Loss) on Investments [Table Text Block] Financial Instruments [Domain] Financial Instruments [Domain] Cost of sales Cost of Goods and Services Sold Entity Central Index Key Entity Central Index Key Eligible employee purchase price percentage of fair value Share-based Compensation Arrangement by Share-based Payment Award, Eligible Employee Purchase Price Percentage of Fair Value This element represents the percentage of the fair market value of the entity's common stock on the first day of the applicable offering period or last day of the applicable purchase period that eligible employees may purchase shares of the entity's common stock under the employee stock purchase plan. Antidilutive Securities Excluded from Computation of Earnings Per Share Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Net lease cost Lease, Cost Exercise price, high end of range ( in usd per share) Share-based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit Shareholders’ equity: Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest [Abstract] Decreases related to prior period tax positions Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions TRIKAFTA/KAFTRIO TRIKAFTA/KAFTRIO [Member] TRIKAFTA/KAFTRIO Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Other Other Countries Outside of the United States and Europe [Member] Other Countries Outside of the United States and Europe [Member] Other long-term liabilities Other Liabilities, Noncurrent Gross Amounts Offset Derivative Asset, Fair Value, Gross Liability Trading Symbol Trading Symbol Number of installments Share-based Compensation Arrangement By Share-based Payment Award, Number Of Installments Share-based Compensation Arrangement By Share-based Payment Award, Number Of Installments Gross Amounts Presented Derivative Asset Other Deferred Tax Liabilities, Other Gross Amounts Offset Derivative Liability, Fair Value, Gross Asset Other current liabilities Other Current Liabilities [Member] Line of Credit Facility [Table] Line of Credit Facility [Table] Tranche three Share-based Payment Arrangement, Tranche Three [Member] Lease agreements number of buildings Lease Agreements Number of Buildings Represents number of buildings under lease agreements. Thereafter Finance Lease And Operating Lease, Liability, Payments, Due After Year Five Finance Lease And Operating Lease, Liability, Payments, Due After Year Five Stock-based compensation expense related to inventories Share-based Payment Arrangement, Expense Exercisable (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Other current liabilities Other Liabilities, Current [Abstract] Reclassification out of Accumulated Other Comprehensive Income [Domain] Reclassification out of Accumulated Other Comprehensive Income [Domain] Government-sponsored enterprise securities US Government-sponsored Enterprises Debt Securities [Member] Schedule of Components of Income Before Provision for (Benefit From) Income Taxes Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Cash, cash equivalents and restricted cash—beginning of period Cash, cash equivalents and restricted cash—end of period Cash, cash equivalents and restricted cash per consolidated statement of cash flows Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Common stock, par value ( in usd per share) Common Stock, Par or Stated Value Per Share Current assets: Assets, Current [Abstract] Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Other financing activities Proceeds from (Payments for) Other Financing Activities Cash equivalents: Cash and Cash Equivalents, Fair Value Disclosure Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercise Price Range [Domain] Exercise Price Range [Domain] Recurring basis Fair Value, Recurring [Member] Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible List] Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Statute of limitations expiration Unrecognized Tax Benefits, Reduction Resulting from Lapse of Applicable Statute of Limitations On Foreign Currency Forward Contracts Accumulated Gain (Loss), Net, Cash Flow Hedge, Parent [Member] Schedule of Potential Gross Common Equivalent Shares Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Auditor Firm ID Auditor Firm ID Net cash (used in) provided by investing activities Net Cash Provided by (Used in) Investing Activities Buildings and improvements Building and Building Improvements [Member] Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Performance period Share-Based Compensation by Share-Based Payment Award, Performance Period Share-Based Compensation by Share-Based Payment Award, Performance Period Vested ( in usd per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Gross Unrealized Losses Debt and Equity Securities, Unrealized Loss Debt and Equity Securities, Unrealized Loss Euro Euro Member Countries, Euro Line of credit facility, maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Operating cash flows from finance leases Finance Lease, Interest Payment on Liability Total product revenues outside of the United States Total long-lived assets outside of the United States Outside the United States [Member] Outside the United States [Member] Line of Credit Facility [Line Items] Line of Credit Facility [Line Items] Total long-lived assets Long-Lived Assets Other Other Assets, Current Prepaid expenses and other current assets Prepaid Expenses and Other Current Assets [Member] Schedule of Offsetting Liabilities Offsetting Liabilities [Table Text Block] Gross Amounts Recognized Derivative Liability, Fair Value, Gross Liability Right to license, number of targets (up to) Collaborative Arrangement, Right To License, Number Of Targets Collaborative Arrangement, Right To License, Number Of Targets Schedule of Reconciliation of the Provision for (Benefit From) Income Taxes Income Tax Expense (Benefit) Continuing Operations, Income Tax Reconciliation [Table Text Block] This block of text may be used to disclose all or parts of the required information for reconciliation of income tax provisions. Options outstanding (in shares) Share-based Payment Arrangement, Option, Exercise Price Range, Shares Outstanding Cost of sales Cost of Sales [Member] Name of Property [Domain] Name of Property [Domain] Inventories Inventory, Policy [Policy Text Block] Debt covenant, minimum consolidated EBITDA Debt Covenant, interest Coverage Ratio Minimum consolidated EBITDA that must be maintained in order to be in compliance with debt covenants. Foreign Current Foreign Tax Expense (Benefit) Matures within one year Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Schedule of Assumptions Used to Estimate the Grant Date Fair Value Employee Stock Purchase Plan Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block] Adjustments to reconcile net income to net cash provided by operating activities: Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Offering period (in months) Share-based Compensation Arrangement by Share-based Payment Award, Offering Period Share-based Compensation Arrangement by Share-based Payment Award, Offering Period Aggregate Intrinsic Value Aggregate intrinsic value [Abstract] -- None. No documentation exists for this element. --