UNITED STATES
              SECURITIES AND EXCHANGE COMMISSION
                    Washington, D.C.  20549



                         SCHEDULE 13G


           Under the Securities Exchange Act of 1934

                     (Amendment No. One )*

              VERTEX PHARMACEUTICALS INCORPORATED

                       (Name of Issuer)

                         COMMON SHARES

                (Title of Class of Securities)

                           92532F100
                        (CUSIP Number)

                       DECEMBER 31, 1998
    (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

     [x] Rule 13d-1(b)
     [ ] Rule 13d-1(c)
     [ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section
of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).







Potential persons who are to respond to the collection of information
contained in this form are not required to respond unless the form displays
a currently valid OMB control number.







CUSIP No. 92532F100      Schedule 13G              Page 2 of 5

1.     Name of Reporting Persons.
  I.R.S. Identification Nos. of above persons (entities only).

  Mackenzie Financial Corporation 

2.     Check the Appropriate Box if a Member of a Group  (a) [ ]
                                               (b) [x]
3.     SEC Use Only

4.     Citizenship or Place of Organization 

  Toronto, Ontario, Canada

Number of Shares Beneficially Owned by Each Reporting Person With:  

5. Sole Voting Power

   741,000 Shares      

6. Shared Voting Power

   27,900 Shares

7. Sole Dispositive Power

   741,000 Shares

8. Shared Dispositive Power

   27,900 Shares

9. Aggregate Amount Beneficially Owned by Each Reporting Person 

   768,900    Shares

10.     Check if the Aggregate Amount in Row (11) Excludes Certain Shares
   
   N/A

11.     Percent of Class Represented by Amount in Row (9)

   3.0%

12.     Type of Reporting Person (See Instructions)

   IA, HC





Item 1.                  Schedule 13G              Page 3 of 5

    (a) Name of Issuer

        Vertex Pharmaceuticals Incorporated

    (b) Address of Issuer's Principal Executive Offices

        130 Waverly Street
        Cambridge, MA
        02139-4242
        

Item 2.

    (a) Name of Person Filing

        Mackenzie Financial Corporation 

    (b) Address of Principal Business Office or, if none, Residence

        150 Bloor Street West, Suite M111, Toronto, Ontario  M5S 3B5

    (c) Citizenship

        Organized in Toronto, Ontario, Canada

    (d) Title of Class of Securities  

        Common Stock

    (e) CUSIP Number

        92532F100


Item 3.  If this statement is filed pursuant to 240.13d-1(b) or 240.13d-2(b),
or (c) check whether the person filing is a(n):

    (a) [ ] Broker or dealer registered under section 15 of the Act (15
            U.S.C.78o).
    (b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
    (c) [ ] Insurance Company as defined in section 3(a)(19) of the Act
            (15 U.S.C.78c).
    (d) [ ] Investment Company registered under section 8 of the
            Investment Company Act of 1940 (15 U.S.C. 80a-8).
    (e) [X] investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);
    (f) [ ] employee benefit plan or endowment fund in accordance with
            240.13d-1(b)(1)(ii)(F);
    (g) [X] parent holding company or control person in accordance with
            240.13d-1(b)(1)(ii)(G);
    (h) [ ] savings associations as defined in Section 3(b) of the Federal
            Deposit Insurance Act (12 U.S.C. 1813);








                         Schedule 13G              Page 4 of 5

    (i) [ ] church plan that is excluded from the definition of an
            investment company under section 3(c)(14) of the Investment
            Company Act of 1940 (15 U.S.C. 80a-3);
    (j) [ ] Group, in accordance with 240.13d-1(b)(1)(ii)(J).


Item 4. Ownership

Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.
 
    (a) Amount beneficially owned: 768,900 .

    (b) Percent of Class: 3.0%.

    (c) Number of shares as to which such person has:

        (i)  Sole power to vote or to direct the vote 741,000 .

        (ii) Shared power to vote or to direct the vote 27,900 .

        (iii)  Sole power to dispose or to direct the disposition of
               741,000 .

        (iv) Shared power to dispose or to direct the disposition of
             27,900.


Item 5. Ownership of Five Percent or Less of a Class

    If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following [X].


Item 6. Ownership of More than Five Percent on Behalf of Another Person

    N/A

Item 7. Identification and Classification of the Subsidiary Which Acquired
        the Security Being Reported on By the Parent Holding Company

    Various portfolios under Ivy Fund, a registered investment company, hold
Vertex Pharmaceuticals Incorporated.  Ivy Management, Inc. provides business
management and investment advisory services to each portfolio and is a wholly
owned subsidiary of Mackenzie Investment Management Inc..  Mackenzie
Investment Management Inc. is a majority-owned subsidiary of Mackenzie
Financial Corporation.

Item 8. Identification and Classification of Members of the Group

    N/A

Item 9. Notice of Dissolution of Group

    N/A





                         Schedule 13G              Page 5 of 5



Item 10.  Certification

(a) The following certification shall be included if the statement is filed
    pursuant to 240.13d-1(b):

    By signing below I certify that, to the best of my knowledge and
    belief, the securities referred to above were acquired in the ordinary
    course of business and were not acquired and are not held for the
    purpose of or with the effect of changing or influencing the control of
    the issuer of the securities and were not acquired and are not held in
    connection with or as a participant in any transaction having that
    purpose or effect.

(b) The following certification shall be included if the statement is filed
    pursuant to 240.13d-1(c):

    By signing below I certify that, to the best of my knowledge and
    belief, the securities referred to above were not acquired and are not
    held for the purpose of or with the effect of changing or influencing
    the control of the issuer of the securities and were not acquired and
    are not held in connection with or as a participant in any transaction
    having that purpose or effect.

                           SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

    IVY MANAGEMENT, INC.             MACKENZIE FINANCIAL CORPORATION

                                     February 8, 1999   
          Date                               Date             




        Signature                   Signature          
        
                               Harold P. Hands                
                               Executive Vice-President, Legal
       
                                           Name/Title         



    The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative.  If the statement
is signed on behalf of a person by his authorized representative other
than an executive officer or general partner of the filing person,
evidence of the representative's authority to sign on behalf of such
person shall be filed with the statement, provided, however, that a power
of attorney for this purpose which is already on file with the Commission
may be incorporated by reference.  The name and any title of each person
who signs the statement shall be typed or printed beneath his signature.