UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                                 Amendment No. 4

                       VERTEX PHARMACEUTICALS INCORPORATED
                                (Name of Issuer)


                                  COMMON STOCK
                         (Title of Class of Securities)


                                                     92532F100
                                 (CUSIP Number)


       Check the following box if a fee is being paid with this statement ( ).











                                  SCHEDULE 13G
                                 Amendment No. 4

                       VERTEX PHARMACEUTICALS INCORPORATED
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                    92532F100
                                 (CUSIP Number)


(1)    Names of Reporting Persons S.S. or I.R.S. Identification Nos. of Above
       Persons

       Robert C. Krembil

(2)   Check the Appropriate Box if a Member of a Group

       (a)
       (b)        (x)

(3)    SEC Use Only


(4)    Citizenship or Place of Organization

       Robert C. Krembil is a citizen of Canada


Number of       (5)      Sole Voting Power                  25,000 shares
Shares
Benefici-       (6)      Shared Voting Power                NIL
ally Owned
by Each         (7)      Sole Dispositive Power             25,000 shares
Reporting
Person With     (8)      Shared Dispositive Power  NIL


(9)    Aggregate Amount Beneficially Owned by Each Reporting Person

                                               25,000 shares

(10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares

                                             Not applicable

(11)    Percent of Class Represented by Amount in Row 9

                                             0.1 % of outstanding common shares

(12)   Type of Reporting Person             HC  (see item 2A)








                                  SCHEDULE 13G
                                 Amendment No. 4

                       VERTEX PHARMACEUTICALS INCORPORATED
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                    92532F100
                                 (CUSIP Number)


(1)    Names of Reporting Persons S.S. or I.R.S. Identification Nos. of Above
       Persons

       Arthur S. Labatt

(2)   Check the Appropriate Box if a Member of a Group

       (a)
       (b)        (x)

(3)    SEC Use Only


(4)    Citizenship or Place of Organization

       Arthur S. Labatt is a citizen of Canada


Number of       (5)      Sole Voting Power                  10,000 shares
Shares
Benefici-       (6)      Shared Voting Power                NIL
ally Owned
by Each         (7)      Sole Dispositive Power             10,000 shares
Reporting
Person With     (8)      Shared Dispositive Power  NIL


(9)    Aggregate Amount Beneficially Owned by Each Reporting Person

                                               10,000 shares

(10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares

                                             Not applicable

(11)    Percent of Class Represented by Amount in Row 9

                                             0.0  % of outstanding common shares

(12)   Type of Reporting Person             HC  (see item 2A)










                                  SCHEDULE 13G
                                 Amendment No. 4

                       VERTEX PHARMACEUTICALS INCORPORATED
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                    92532F100
                                 (CUSIP Number)


(1)    Names of Reporting Persons S.S. or I.R.S. Identification Nos. of Above
       Persons

       Trimark Financial Corporation

(2)   Check the Appropriate Box if a Member of a Group

       (a)
       (b)        (x)

(3)    SEC Use Only


(4)    Citizenship or Place of Organization

       Trimark Financial Corporation is a corporation incorporated under the
       laws of Ontario, Canada


Number of      (5)      Sole Voting Power               1,974,500 shares
Shares
Benefici-      (6)      Shared Voting Power                NIL
ally Owned
by Each        (7)      Sole Dispositive Power          1,974,500 shares
Reporting
Person With    (8)      Shared Dispositive Power  NIL


(9)    Aggregate Amount Beneficially Owned by Each Reporting Person

                                            1,974,500 shares

(10)    Check if the Aggregate Amount in Row (9) Excludes Certain Shares

                                             Not applicable

(11)    Percent of Class Represented by Amount in Row 9

                                             9.4  % of outstanding common shares

(12)   Type of Reporting Person             HC  (see item 2A)








                                    Item 1(a)

Name of Issuer:   Vertex Pharmaceuticals Incorporated




                                    Item 1(b)

Address of Issuer's Principal Executive Offices:

       130 Waverly Street
       Cambridge, MA 02139


                                    Item 2(a)

Name of Person Filing:

Certain Trimark mutual funds (the "Funds"), which are trusts organized under the
laws of Ontario,  Canada, are owners of record of the securities covered by this
report.  Robert C. Krembil, a Canadian citizen,  and Chairman and shareholder of
Trimark Financial Corporation ("TFC"), and Arthur S. Labatt, a Canadian citizen,
and President and shareholder of Trimark Financial Corporation ("TFC"), are also
owners of record of a portion of the securities covered by this report.  Trimark
Investment  Management Inc. ("TIMI"), a corporation  incorporated under the laws
of Canada, is a manager and trustee of the Funds. TIMI is qualified to act as an
investment  adviser and manager of the Funds in the province of Ontario pursuant
to  a  registration  under  the  Securities  Act  (Ontario).  Trimark  Financial
Corporation  ("TFC") is a  corporation  incorporated  under the laws of Ontario,
Canada. It owns 100% of the voting equity securities of TIMI. Consequently,  TFC
may be deemed to be the beneficial owner of such securities.


                                    Item 2(b)

Address of Principal Business Office:

                            One First Canadian Place
                            Suite 5600, P.O. Box 487
                                Toronto, Ontario
                                     M5X 1E5

                                 (416) 362-7181



                                    Item 2(c)

Citizenship:

Robert C. Krembil - Canada
Arthur S. Labatt - Canada
Trimark Financial Corporation - Incorporated under the laws of Ontario, Canada
Trimark Investment Management Inc. - Incorporated under the laws of Canada

Trimark mutual funds - mutual fund trusts organized under the laws of Ontario








                                    Item 2(d)

Title of Class of Securities:       common stock



                                    Item 2(e)

CUSIP Number:                       92532F100



                                     Item 3

If this  statement  is filed  pursuant to Rules  13d-1(b),  or  13d-2(b),  check
whether the person filing is a:

       (a)      (   )   Broker or Dealer registered under Section 15 of the Act

       (b)      (   )   Bank as defined in section 3(a) (6) of the Act

       (c)      (   )   Insurance Company as defined in section 3(a)(19) of the
                        Act

       (d)      (   )   Investment Company registered under section 8 of the
                        Investment Company Act

       (e)      (   )   Investment Adviser registered under section 203 of the
                        Investment Advisers Act of 1940

       (f)      (   )   Employee Benefit Plan, Pension Fund which is subject to
                        the provisions of the Employee Retirement Income
                        Security Act of 1974 or Endowment Fund; see 240.13d-1(b)
                        (1) (ii)(F)

       (g)      (x )    Parent Holding Company, in accordance with 240.13d-1(b)
                        (ii)(G)
                        (Note:  See Item 7)

       (h)      (   )   Group, in accordance with 240.13d-1(b) (ii)(H)

                            (see item 2A)


                                     Item 4

Ownership.

       (a)      Amount Beneficially Owned*:

                            2,009,500       shares

       (b)      Percent of Class:

                            9.5     %







       (c)      Number of shares as to which such person has*:

(i)    sole power to vote or to direct the vote: (TFC)                 2,009,500
(ii)   shared power to vote or to direct the vote:                           NIL
(iii)  sole power to dispose or to direct the disposition of: (TFC)    2,009,500
(iv)   shared power to dispose or to direct the disposition of:              NIL

    *      (see item 2(a))





                                     Item 5

Ownership of Five Percent or Less of a Class

       Inapplicable



                                     Item 6

Ownership of More than Five Percent on Behalf of Another Person

       Inapplicable



                                     Item 7

Identification  and Classification of the Subsidiary which Acquired the Security
Being Reported on By the Parent Holding Company.

       See item 2(a)



                                     Item 8

Identification and Classification of Members of the Group.

       Inapplicable



                                     Item 9

Notice of Dissolution of Group.

       Inapplicable










                                     Item 10

Certification.

       By signing  below I certify that, to the best of my knowledge and belief,
the  securities  referred  to above  were  acquired  in the  ordinary  course of
business  and were not acquired for the purpose of and do not have the effect of
changing or  influencing  the control of the issuer of such  securities and were
not acquired in connection  with or as a participant in any  transaction  having
such purposes or effect.

Signature.

       After  reasonable  inquiry and to the best of my knowledge and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Date:                  February 5, 1997


Signature:

Name/Title:   Michael Kevin Feeney, Chief Financial Officer, on behalf of
              Trimark Financial Corporation in its capacity as a "Reporting
              Person" herein.


              Attention:  Intentional misstatements or omissions of fact
              constitute Federal criminal violations (See 18 U.S.C. 1001).