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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 10-C

                 REPORT BY ISSUER OF SECURITIES QUOTED ON NASDAQ
                          INTERDEALER QUOTATION SYSTEM
                 FILED PURSUANT TO SECTION 13 OR 15 (d) OF THE
                SECURITIES EXCHANGE ACT OF 1934 AND RULES 13a-17
                              AND 15d-17 THEREUNDER


                     Vertex Pharmaceuticals Incorporated
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                 (Exact name of issuer as specified in charter)


                              130 Waverley Street
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                    (Address of principal executive offices)

Issuer's telephone number, including are code  (617) 577-6000
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                   I. CHANGE IN NUMBER OF SHARES OUTSTANDING

Indicate any change (increase or decrease) of five percent or more in the number
of shares outstanding:

1. Title of security        Common Stock, $.01 par value per share
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2. Number of shares outstanding before the change   17,358,458
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3. Number of shares outstanding after the change    20,808,458
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4. Effective date of change      August 14, 1996
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5. Method of change: Specify method (such as merger, acquisition, exchange,
distribution, stock split, reverse split, acqusition of stock for treasury,
etc.)           Public Offering
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Give brief description of transaction    3,450,000 shares of Common Stock sold
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                                         in a firm underwritten public offering
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                          II. CHANGE IN NAME OF ISSUER

1. Name prior to change
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2. Name after change
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3. Effective date of charter amendment changing name
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4. Date of shareholder approval of change, if required
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Date     August 15, 1996               /s/ Thomas G. Auchincloss, Jr.
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                                       Senior Director of Finance and Treasurer
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                                       (Officer's signature and title)