Institutional Investors and Financial Analysts, please contact:

Main email: investorinfo@vrtx.com
Main phone: 617-961-7163

Susie Lisa
Senior Vice President, Investor Relations
617-341-6108

Manisha Pai
Executive Director, Investor Relations
617-961-1899

Miroslava Minkova
Executive Director, Investor Relations
617-341-6135

Contact Vertex's Transfer Agent
Communication regarding transfer requirements, lost certificates and changes of address should be directed to:

Computershare Investor Services
P.O. Box 43006
Providence, RI 02940-3006
Phone: 877-373-6374
Website: www-us.computershare.com

Overnight:
Computershare Investor Services
150 Royall Street, Suite 101
Canton, MA 02021